Aptazapine
Names
[ CAS No. ]:
71576-41-5
[ Name ]:
Aptazapine
[Synonym ]:
2H,10H-Pyrazino(1,2-a)pyrrolo(2,1-c)(1,4)benzodiazepine,1,3,4,14b-tetrahydro-2-methyl-,(+-)-,(Z)-2-butenedioate (1:1)
CGS-7525A
Aptazapine maleate (USAN)
C16H19N3.C4H4O4
Chemical & Physical Properties
[ Molecular Formula ]:
C20H23N3O4
[ Molecular Weight ]:
369.41400
[ Exact Mass ]:
369.16900
[ PSA ]:
86.01000
[ LogP ]:
2.05760
Toxicological Information
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- UQ4730325
- CAS REGISTRY NUMBER :
- 71576-41-5
- LAST UPDATED :
- 199512
- DATA ITEMS CITED :
- 3
- MOLECULAR FORMULA :
- C16-H19-N3.C4-H4-O4
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 43680 mg/kg/2Y-I
- TOXIC EFFECTS :
- Cardiac - other changes Endocrine - other changes Kidney, Ureter, Bladder - other changes
- REFERENCE :
- TOXID9 Toxicologist. (Soc. of Toxicology, Inc., 475 Wolf Ledge Parkway, Akron, OH 44311) V.1- 1981- Volume(issue)/page/year: 6,46,1986
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 32760 mg/kg/78W-I
- TOXIC EFFECTS :
- Cardiac - other changes Liver - other changes Kidney, Ureter, Bladder - other changes
- REFERENCE :
- TOXID9 Toxicologist. (Soc. of Toxicology, Inc., 475 Wolf Ledge Parkway, Akron, OH 44311) V.1- 1981- Volume(issue)/page/year: 6,46,1986
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Mammal - dog
- DOSE/DURATION :
- 1092 mg/kg/52W-I
- TOXIC EFFECTS :
- Brain and Coverings - other degenerative changes Liver - other changes Kidney, Ureter, Bladder - other changes
- REFERENCE :
- TOXID9 Toxicologist. (Soc. of Toxicology, Inc., 475 Wolf Ledge Parkway, Akron, OH 44311) V.1- 1981- Volume(issue)/page/year: 6,46,1986