p,p'-DDD

Names

[ CAS No. ]:
72-54-8

[ Name ]:
p,p'-DDD

[Synonym ]:
1-chloro-4-[2,2-dichloro-1-(4-chlorophenyl)ethyl]benzene
EINECS 200-783-0
4,4'-DDD
P,P'-DDD
DDD
p,p'-Dichlorodiphenyldichloroethane
1,1’-(2,2-dichloroethylidene)bis[4-chlorobenzene]
1,1-Dichloro-2,2-bis(4-chlorophenyl)-ethane
1,1'-(2,2-dichloroethane-1,1-diyl)bis(4-chlorobenzene)
1,1-Bis(4-chlorophenyl)-2,2-dichloroethane
p,p'-(Dichlorodiphenyl)dichloroethane
2,2-Bis(4-chlorophenyl)-1,1-dichloroethane
DDD, p,p'-
Benzene, 1,1'-(2,2-dichloroethylidene)bis[4-chloro-
1,1-Dichloro-2,2-bis(4-chlorophenyl)ethane
TDE
MFCD00000851
4,4′-DDD
1,1'-(2,2-Dichloro-1,1-ethanediyl)bis(4-chlorobenzene)
Dichlorodiphenyldichloroethane
1,1’-(2,2-dichloroethane-1,1-diyl)bis(4-chlorobenzene)

Biological Activity

[Description]:

p,p'-DDD is a major metabolite of p,p'-DDT. p,p'-DDD occurs in the feces and livers of rats, that are given p,p'-DDT by stomach tube, but not of rats injected intraperitoneally with p,p'-DDT[1][2].

[Related Catalog]:

Research Areas >> Others

[References]

[1]. Mendel JL, et al. Conversion of p,p' -DDT to p,p' -DDD by intestinal flora of the rat. Science. 1966;151(3717):1527-1528.

[2]. Gerić M, et al. Cytogenetic status of human lymphocytes after exposure to low concentrations of p,p'-DDT, and its metabolites (p,p'-DDE, and p,p'-DDD) in vitro. Chemosphere. 2012;87(11):1288-1294.

Chemical & Physical Properties

[ Density]:
1.4±0.1 g/cm3

[ Boiling Point ]:
405.7±40.0 °C at 760 mmHg

[ Melting Point ]:
94-96 °C

[ Molecular Formula ]:
C₁₄H₁₀Cl₄

[ Molecular Weight ]:
320.041

[ Flash Point ]:
199.3±24.7 °C

[ Exact Mass ]:
317.953674

[ LogP ]:
5.39

[ Vapour Pressure ]:
0.0±0.9 mmHg at 25°C

[ Index of Refraction ]:
1.599

[ Stability ]:
Stable. Incompatible with strong oxidizing agents.

MSDS

Click to get detail MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: KI0700000

CHEMICAL NAME :: Ethane, 1,1-dichloro-2,2-bis(p-chlorophenyl)-

CAS REGISTRY NUMBER :: 72-54-8

BEILSTEIN REFERENCE NO. :: 1914072

LAST UPDATED :: 199710

DATA ITEMS CITED :: 24

MOLECULAR FORMULA :: C14-H10-Cl4

MOLECULAR WEIGHT :: 320.04

WISWESSER LINE NOTATION :: GYGYR DG&R DG

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 113 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 600 mg/kg

TOXIC EFFECTS :: Behavioral - tremor Behavioral - convulsions or effect on seizure threshold Behavioral - excitement

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: 1200 mg/kg

TOXIC EFFECTS :: Behavioral - excitement Behavioral - convulsions or effect on seizure threshold Skin and Appendages - primary irritation (after topical exposure)

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - hamster

DOSE/DURATION :: >5 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 504 mg/kg/6W-C

TOXIC EFFECTS :: Endocrine - changes in spleen weight Immunological Including Allergic - decrease in cellular immune response Immunological Including Allergic - decrease in humoral immune response

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 54 gm/kg/78W-C

TOXIC EFFECTS :: Tumorigenic - equivocal tumorigenic agent by RTECS criteria Endocrine - thyroid tumors

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 39 gm/kg/2Y-C

TOXIC EFFECTS :: Tumorigenic - neoplastic by RTECS criteria Lungs, Thorax, or Respiration - tumors Liver - tumors

MUTATION DATA

TYPE OF TEST :: Host-mediated assay

TEST SYSTEM :: Rodent - mouse Bacteria - Serratia marcescens

DOSE/DURATION :: 1500 mg/kg

REFERENCE :: BIZNAT Biologisches Zentralblatt. (VEB Georg Thieme, Postfach 946, Leipzig DDR-7010, Ger. Dem. Rep.) V.1- 1881- Volume(issue)/page/year: 91,311,1972 *** REVIEWS *** IARC Cancer Review:Animal Sufficient Evidence IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 5,83,1974 IARC Cancer Review:Animal Sufficient Evidence IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 53,179,1991 IARC Cancer Review:Human Inadequate Evidence IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 53,179,1991 IARC Cancer Review:Group 2B IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 53,179,1991 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X5013 No. of Facilities: 7 (estimated) No. of Industries: 1 No. of Occupations: 1 No. of Employees: 14 (estimated)

Safety Information

[ Symbol ]:

GHS02, GHS06, GHS08, GHS09

[ Signal Word ]:
Danger

[ Hazard Statements ]:
H225-H301 + H311 + H331-H370-H410

[ Precautionary Statements ]:
P210-P260-P273-P280-P301 + P310-P311

[ Personal Protective Equipment ]:
Eyeshields;Faceshields;full-face respirator (US);Gloves;multi-purpose combination respirator cartridge (US)

[ Hazard Codes ]:
T,N,F

[ Risk Phrases ]:
R23/24/25

[ Safety Phrases ]:
S36/37-S45-S60-S61-S16-S7

[ RIDADR ]:
UN 2811 6.1/PG 3

[ WGK Germany ]:
3

[ RTECS ]:
KI0700000

[ Packaging Group ]:
III

[ Hazard Class ]:
6.1(b)

[ HS Code ]:
2903999090

Synthetic Route

Click to get detail synthetic route

Customs

[ HS Code ]: 2903999090

[ Summary ]:
2903999090 halogenated derivatives of aromatic hydrocarbons VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:5.5% General tariff:30.0%

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