Metandienone
Names
[ CAS No. ]:
72-63-9
[ Name ]:
Metandienone
[Synonym ]:
1-Dehydro-17a-methyltestosterone
Androsta-1,4-dien-3-one, 17β-hydroxy-17α-methyl-
Androsta-1,4-dien-3-one, 17β-hydroxy-17-methyl-
1-Dehydro-17α-methyltestosterone
Androsta-1,4-dien-3-one, 17-hydroxy-17-methyl-, (17β)-
EINECS 200-787-2
(17β)-17-Hydroxy-17-methylandrosta-1,4-dien-3-one
17a-Methyl-17b-hydroxyandrosta-1,4-dien-3-one
17-β-hydroxy-17-methyl-androsta-1,4-dien-3-one (9CI)
Metandienone
(17b)-17-Hydroxy-17-methylandrosta-1,4-dien-3-one
Nabolin
17-β-hydroxy-17-methyl-androsta-1,4-dien-3-one
Methandienone
Methandrostenolone
MFCD00003650
Chemical & Physical Properties
[ Density]:
1.1±0.1 g/cm3
[ Boiling Point ]:
436.5±45.0 °C at 760 mmHg
[ Melting Point ]:
165-166 °C
[ Molecular Formula ]:
C20H28O2
[ Molecular Weight ]:
300.435
[ Flash Point ]:
186.2±21.3 °C
[ Exact Mass ]:
300.208923
[ PSA ]:
37.30000
[ LogP ]:
4.04
[ Vapour Pressure ]:
0.0±2.4 mmHg at 25°C
[ Index of Refraction ]:
1.572
[ Storage condition ]:
2-8°C
MSDS
Toxicological Information
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- BV8000000
- CHEMICAL NAME :
- Androsta-1,4-dien-3-one, 17-beta-hydroxy-17-alpha-methyl-
- CAS REGISTRY NUMBER :
- 72-63-9
- LAST UPDATED :
- 199504
- WISWESSER LINE NOTATION :
- L E5 B666 OV AHTTT&J A1 E1 FQ F1
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- >1 gm/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 425 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Human - man
- DOSE/DURATION :
- 561 mg/kg/7Y-C
- TOXIC EFFECTS :
- Tumorigenic - Carcinogenic by RTECS criteria Liver - tumors
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- DOSE :
- 13 mg/kg
- SEX/DURATION :
- male 60 day(s) pre-mating
- TOXIC EFFECTS :
- Reproductive - Paternal Effects - spermatogenesis (incl. genetic material, sperm morphology, motility, and count)
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- DOSE :
- 200 mg/kg
- SEX/DURATION :
- female 10 day(s) pre-mating
- TOXIC EFFECTS :
- Reproductive - Maternal Effects - ovaries, fallopian tubes Reproductive - Maternal Effects - uterus, cervix, vagina
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- DOSE :
- 200 mg/kg
- SEX/DURATION :
- male 10 day(s) pre-mating
- TOXIC EFFECTS :
- Reproductive - Paternal Effects - testes, epididymis, sperm duct Reproductive - Paternal Effects - other effects on male
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Subcutaneous
- DOSE :
- 7 mg/kg
- SEX/DURATION :
- female 14 day(s) pre-mating
- TOXIC EFFECTS :
- Reproductive - Maternal Effects - ovaries, fallopian tubes Reproductive - Maternal Effects - uterus, cervix, vagina Reproductive - Fertility - other measures of fertility
MUTATION DATA
- TEST SYSTEM :
- Rodent - mouse
- DOSE/DURATION :
- 200 mg/kg/10D (Intermittent)
- REFERENCE :
- VPITAR Voprosy Pitaniya. Problems of Nutrition. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1-10, 1932-41; V.11- 1952- Volume(issue)/page/year: 38(4),63,1980 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X5642 No. of Facilities: 25 (estimated) No. of Industries: 1 No. of Occupations: 1 No. of Employees: 157 (estimated) No. of Female Employees: 72 (estimated)
Safety Information
[ Symbol ]:
GHS02, GHS07, GHS08
[ Signal Word ]:
Danger
[ Hazard Statements ]:
H225-H315-H360FD
[ Supplemental HS ]:
May form explosive peroxides.
[ Precautionary Statements ]:
P201-P210-P280-P308 + P313-P370 + P378-P403 + P235
[ Hazard Codes ]:
F,T
[ Risk Phrases ]:
60-61-11-19-38
[ Safety Phrases ]:
53-45
[ RIDADR ]:
3249
[ WGK Germany ]:
3
[ RTECS ]:
BV8000000
[ Packaging Group ]:
III
[ Hazard Class ]:
6.1(b)
[ HS Code ]:
2942000000
Synthetic Route
Precursor & DownStream
Precursor
DownStream
Customs
[ HS Code ]: 2942000000
Articles
BMJ Case Rep. 2013 , doi:10.1136/bcr-2012-007577, (2013)
The patient is a 52-year-old man with schizophrenia who developed severe, unremitting gingival pain after his ziprasidone dosage was increased from 80 to 120 mg. His physical examination and laborator...
Screening for anabolic steroids in urine of forensic cases using fully automated solid phase extraction and LC-MS-MS.J. Anal. Toxicol. 38(9) , 637-44, (2014)
A screening method for 18 frequently measured exogenous anabolic steroids and the testosterone/epitestosterone (T/E) ratio in forensic cases has been developed and validated. The method involves a ful...
Mass spectrometric behavior of anabolic androgenic steroids using gas chromatography coupled to atmospheric pressure chemical ionization source. Part I: ionization.J. Mass Spectrom. 49(6) , 509-21, (2014)
The detection of anabolic androgenic steroids (AAS) is one of the most important topics in doping control analysis. Gas chromatography coupled to (tandem) mass spectrometry (GC-MS(/MS)) with electron ...