Leukotriene C4

Names

[ CAS No. ]:
72025-60-6

[ Name ]:
Leukotriene C4

[Synonym ]:
L-γ-glutamyl-S-[(1R,2E,4E,6Z,9Z)-1-[(1S)-4-carboxy-1-hydroxybutyl]-2,4,6,9-pentadecatetraenyl]-L-cysteinyl-glycine
7,9,11,14-Eicosatetraenoic acid, 6-[[(2R,3Z)-2-[[(1E,4S)-4-amino-4-carboxy-1-hydroxybutylidene]amino]-3-[(carboxymethyl)imino]-3-hydroxypropyl]thio]-5-hydroxy-, (5S,6R,7E,9E,11Z,14Z)-
L-γ-Glutamyl-S-[(4S,5R,6E,8E,10Z,13Z)-1-carboxy-4-hydroxy-6,8,10,13-nonadecatetraen-5-yl]-L-cysteinylglycine
leukotriene C1
Leukotriene C4
leucotriene C-1
Leukotriene C4 Lipid Maps MS Standard
Leucotriene C4
(5S,6R,7E,9E,11Z,14Z)-6-({(2R,3Z)-2-{(E)-[(4S)-4-Amino-4-carboxy-1-hydroxybutylidene]amino}-3-[(carboxymethyl)imino]-3-hydroxypropyl}sulfanyl)-5-hydroxy-7,9,11,14-icosatetraenoic acid
LTC4
Glycine, L-γ-glutamyl-S-[(1R,2E,4E,6Z,9Z)-1-[(1S)-4-carboxy-1-hydroxybutyl]-2,4,6,9-pentadecatetraen-1-yl]-L-cysteinyl-
leukotrienec
MFCD00151079

Biological Activity

[Description]:

Leukotriene C4 is the parent cysteinyl leukotriene produced by the LTC4 synthase catalyzed conjugation of glutathione to LTA4. Leukotriene C4 is produced by neutrophils, macrophages, mast cells, and by transcellular metabolism in platelets. Leukotriene C4 is one of the constituents of slow-reacting substance of anaphylaxis (SRS-A) and exhibits potent smooth muscle contracting activity.

[Target]

Human Endogenous Metabolite

Chemical & Physical Properties

[ Density]:
1.2±0.1 g/cm3

[ Boiling Point ]:
974.3±65.0 °C at 760 mmHg

[ Molecular Formula ]:
C₃₀H₄₇N₃O₉S

[ Molecular Weight ]:
625.774

[ Flash Point ]:
543.1±34.3 °C

[ Exact Mass ]:
625.303284

[ PSA ]:
241.65000

[ LogP ]:
4.35

[ Vapour Pressure ]:
0.0±0.6 mmHg at 25°C

[ Index of Refraction ]:
1.564

MSDS

Click to get detail MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: MB9143500

CHEMICAL NAME :: Glycine, N-(S-(1-(4-carboxy-1-hydroxybutyl)-2,4,6,9-pentadecat etraenyl)-N-L-gamma-g lutamyl-L- cysteinyl)-, (R-(R*,S*-(E,E,Z,Z)))-

CAS REGISTRY NUMBER :: 72025-60-6

LAST UPDATED :: 198912

DATA ITEMS CITED :: 1

MOLECULAR FORMULA :: C30-H47-N3-O9-S

MOLECULAR WEIGHT :: 625.86

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

MUTATION DATA

TYPE OF TEST :: Unscheduled DNA synthesis

TEST SYSTEM :: Human Cells - not otherwise specified

DOSE/DURATION :: 10 nmol/L

REFERENCE :: JCINAO Journal of Clinical Investigation. (Rockefeller Univ. Press, 1230 York Ave., New York, NY 10021) V.1- 1924- Volume(issue)/page/year: 76,374,1985

Safety Information

[ Hazard Codes ]:
F: Flammable;T: Toxic;

[ Risk Phrases ]:
11-23/24/25-39/23/24/25

[ Safety Phrases ]:
36/37-45

[ RIDADR ]:
UN 1230 3/PG 2