β-Funaltrexamine hydrochloride,(E)-4-[[5α,6β)-17-Cyclopropylmethyl)-4,5-epoxy-3,14-dihydroxymorphinan-6-yl]amino]-4-oxo-2-butenoicacidmethylesterhydrochloride
Names
[ CAS No. ]:
72786-10-8
[ Name ]:
β-Funaltrexamine hydrochloride,(E)-4-[[5α,6β)-17-Cyclopropylmethyl)-4,5-epoxy-3,14-dihydroxymorphinan-6-yl]amino]-4-oxo-2-butenoicacidmethylesterhydrochloride
[Synonym ]:
b-FunaltrexamineHCl
Chemical & Physical Properties
[ Boiling Point ]:
695.2ºC at 760 mmHg
[ Molecular Formula ]:
C25H31ClN2O6
[ Molecular Weight ]:
490.97600
[ Flash Point ]:
374.2ºC
[ Exact Mass ]:
490.18700
[ PSA ]:
108.33000
[ LogP ]:
2.30110
MSDS
Safety Information
[ Personal Protective Equipment ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
[ RIDADR ]:
NONH for all modes of transport
[ WGK Germany ]:
3
Articles
J. Pharmacol. Exp. Ther. 350(1) , 69-78, (2014)
The opioid and cannabinoid systems play a crucial role in multiple physiological processes in the central nervous system and in the periphery. Selective opioid as well as cannabinoid (CB) receptor ago...
Activation of the cloned human kappa opioid receptor by agonists enhances [35S]GTPgammaS binding to membranes: determination of potencies and efficacies of ligands.J. Pharmacol. Exp. Ther. 282 , 676, (1997)
Activation of kappa receptors inhibits adenylate cyclase, enhances K+ conductance and reduces Ca++ conductance via pertussis toxin-sensitive G proteins. We recently cloned a human kappa opioid recepto...
Activation of phosphatidylinositol 3-kinase/Akt-mammalian target of Rapamycin signaling pathway in the hippocampus is essential for the acquisition of morphine-induced place preference in rats.Neuroscience 171(1) , 134-43, (2010)
Hippocampus is a critical structure for the acquisition of morphine-induced conditioned place preference (CPP), which is a usual learning paradigm for assessing drug reward. However, the precise mecha...