2,4,6-Tri-tert-butylphenol

Names

[ CAS No. ]:
732-26-3

[ Name ]:
2,4,6-Tri-tert-butylphenol

[Synonym ]:
MFCD00008821
2,4,6-tri-tert-butyl phenol
2,4,6-Tri-tert-butylphenol
2,4,6-tritert-butylphenol
2,4,6-Tri-tert-butylbenzolol
EINECS 211-989-5
2,4,6-Tris(2-methyl-2-propanyl)phenol
2,4,6-TRI(TERT-BUTYL)PHENOL
Phenol, 2,4,6-tris(1,1-dimethylethyl)-

Chemical & Physical Properties

[ Density]:
0.9±0.1 g/cm3

[ Boiling Point ]:
278.0±0.0 °C at 760 mmHg

[ Melting Point ]:
125-130 °C(lit.)

[ Molecular Formula ]:
C₁₈H₃₀O

[ Molecular Weight ]:
262.430

[ Flash Point ]:
129.3±8.4 °C

[ Exact Mass ]:
262.229675

[ PSA ]:
20.23000

[ LogP ]:
6.55

[ Vapour Pressure ]:
0.0±0.6 mmHg at 25°C

[ Index of Refraction ]:
1.490

[ Storage condition ]:
-20°C

[ Water Solubility ]:
insoluble

MSDS

Click to get detail MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: SN3570000

CHEMICAL NAME :: Phenol, 2,4,6-tris(1,1-dimethylethyl)-

CAS REGISTRY NUMBER :: 732-26-3

LAST UPDATED :: 199710

DATA ITEMS CITED :: 7

MOLECULAR FORMULA :: C18-H30-O

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 1670 mg/kg

TOXIC EFFECTS :: Behavioral - somnolence (general depressed activity) Behavioral - ataxia Liver - other changes

REFERENCE :: SRTCAC Science Reports of the Research Institutes, Tohoku University, Series C: Medicine. (Tohoku University, Research Institute for Tuberculosis and Cancer, 4-1 Seiryo-machi, Sendai, Japan) V.1- 1949- Volume(issue)/page/year: 36(1-4),10,1989 ** OTHER MULTIPLE DOSE TOXICITY DATA **

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 8580 mg/kg/10D-C

TOXIC EFFECTS :: Blood - hemorrhage Related to Chronic Data - death

REFERENCE :: JONUAI Journal of Nutrition. (Subscription Dept., 9650 Rockville Pike, Bethesda, MD 20014) V.1- 1928- Volume(issue)/page/year: 109,453,1979

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 10914 mg/kg/3W-C

TOXIC EFFECTS :: Sense Organs and Special Senses (Olfaction) - effect, not otherwise specified Blood - hemorrhage Related to Chronic Data - death

REFERENCE :: TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year: 46,935,1982 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - M4377 No. of Facilities: 9 (estimated) No. of Industries: 1 No. of Occupations: 1 No. of Employees: 211 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - M4377 No. of Facilities: 279 (estimated) No. of Industries: 4 No. of Occupations: 13 No. of Employees: 12085 (estimated) No. of Female Employees: 239 (estimated)

Safety Information

[ Symbol ]:

GHS07, GHS09

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H302-H400

[ Precautionary Statements ]:
P273-P301 + P312 + P330-P391

[ Personal Protective Equipment ]:
dust mask type N95 (US);Eyeshields;Gloves

[ Hazard Codes ]:
Xi:Irritant;

[ Risk Phrases ]:
R22;R36/37/38

[ Safety Phrases ]:
S26-S36/37/39-S45-S60-S61-S24/25

[ RIDADR ]:
UN 2430 8/PG 3

[ WGK Germany ]:
3

[ RTECS ]:
SN3570000

[ Packaging Group ]:
III

[ Hazard Class ]:
9

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

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Radical production and cytotoxic activity of tert-butyl-substituted phenols.

In Vitr. Mol. Toxicol. 14(1) , 53-63, (2001)

2,4,6-Tri-tert-butylphenol (TBP)-related compounds are used for stabilizing plastics by making them resistant to oxidation. However, the cytotoxic activity of these compounds has not yet been establis...

The role of low levels of water in the electrochemical oxidation of α-tocopherol (vitamin E) and other phenols in acetonitrile.

Phys. Chem. Chem. Phys. 13(28) , 12745-54, (2011)

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