Methylnaltrexone (Bromide)

Names

[ Name ]:
Methylnaltrexone (Bromide)

[Synonym ]:
[14C]-N-Methylnaltrexone bromide
MNTX bromide
Naltrexone methobromide
(-)-naltrexone methyl bromide
Relistor
Methylnaltrexone (Bromide)
MRZ-2663BR
MOA-728
Relistor (TN)
MNTX

Chemical & Physical Properties

[ Melting Point ]:
237-239ºC

[ Molecular Formula ]:
C₂₁H₂₆BrNO₄

[ Molecular Weight ]:
436.33900

[ Exact Mass ]:
435.10500

[ PSA ]:
69.59000

[ LogP ]:
3.02510

MSDS

Click to get detail MSDS

Safety Information

[ Symbol ]:

GHS06, GHS09

[ Signal Word ]:
Danger

[ Hazard Statements ]:
H301-H400

[ Precautionary Statements ]:
P273-P301 + P310

[ RIDADR ]:
UN 2811 6.1 / PGIII

[ RTECS ]:
QD0188550

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Articles

Efficacy of pharmacological therapies for the treatment of opioid-induced constipation: systematic review and meta-analysis.

Am. J. Gastroenterol. 108(10) , 1566-74; quiz 1575, (2013)

There has been no definitive synthesis of the evidence for any benefit of available pharmacological therapies in opioid-induced constipation (OIC). We conducted a systematic review and meta-analysis t...

[Opiate induced constipation--mechanisms, relevance and treatment].

Dtsch. Med. Wochenschr. 138(43) , 2207-11, (2013)

Effects of remifentanil on the esophagogastric junction and swallowing.

Acta Anaesthesiol. Scand. 57(8) , 1002-9, (2013)

A recent study demonstrated that reflux is associated with impaired pressure augmentation in the esophagogastric junction (EGJ), caused by diaphragmal contractions during inspiration. It is unknown wh...