COH-SR4
Names
[ CAS No. ]:
73439-19-7
[ Name ]:
COH-SR4
[Synonym ]:
Urea, N,N'-bis(3,5-dichlorophenyl)-
1,3-Bis(3,5-dichlorophenyl)urea
MFCD01566238
Biological Activity
[Description]:
COH-SR4 (Mitochondria uncoupler SR4) is a bonafide uncoupler that induces energetic stress on cells, consequently leading to AMPK activation and mTOR inhibition without any effects on ERK/MEK MAPK signaling; prevents cell proliferation and promoted cell death in many human cancers including leukemia, lung cancer, melanoma, and hepatocarcinoma in vitro and in animal models; exhibits a strong inhibitory effect on the survival of melanoma cells (B16-F0 cell line IC50=5 uM, Hs600T cell lineI C50=6 uM, and A2058 cell line IC50=11 uM), does not cause any significant cytotoxicity in normal human aortic vascular smooth muscle cells (HAVSMC); inhibits vemurafenib-resistant melanoma in vivo.
[References]
References 1. Singhal SS, et al. Biochem Pharmacol. 2012 Dec 1;84(11):1419-27. 2. Figarola JL, et al. Oncotarget. 2018 Dec 11;9(97):36945-36965. 3. Singhal SS, et al. Biochem Pharmacol. 2013 Dec 15;86(12):1664-72. 4. Figarola JL, et al. PLoS One. 2013 Dec 20;8(12):e83801. View Related Products by Target Other Targets
Chemical & Physical Properties
[ Density]:
1.6±0.1 g/cm3
[ Boiling Point ]:
363.2±42.0 °C at 760 mmHg
[ Melting Point ]:
298-300 °C
[ Molecular Formula ]:
C13H8Cl4N2O
[ Molecular Weight ]:
350.027
[ Flash Point ]:
173.5±27.9 °C
[ Exact Mass ]:
347.939087
[ LogP ]:
7.01
[ Vapour Pressure ]:
0.0±0.8 mmHg at 25°C
[ Index of Refraction ]:
1.706
Safety Information
[ Hazard Codes ]:
Xn