17-N,N-diethylcarbamoyl-4-methyl-4-azaandrostane-3-one

Names

[ Name ]:
17-N,N-diethylcarbamoyl-4-methyl-4-azaandrostane-3-one

Biological Activity

[Description]:

DMAA is an indirect sympathomimetic amine. DMAA constricts blood vessels and raises blood pressure. DMAA can be used for neurological and cardiovascular disease research[1][2].

[Related Catalog]:

Research Areas >> Cardiovascular Disease

Research Areas >> Neurological Disease

[References]

[1]. Rodricks JV, et al. DMAA as a dietary ingredient. JAMA Intern Med. 2013 Apr 8;173(7):594-5.

[2]. Richard J Bloomer, et al. 1,3-Dimethylamylamine (DMAA): A Brief History and Review of Anecdotal and Laboratory Findings. J Altern Complement Integr Med. 2018 Dec 28.

Chemical & Physical Properties

[ Density]:
1.051g/cm3

[ Boiling Point ]:
528.3ºC at 760 mmHg

[ Molecular Formula ]:
C₂₄H₄₀N₂O₂

[ Molecular Weight ]:
388.59

[ Flash Point ]:
209.8ºC

[ Exact Mass ]:
388.30900

[ PSA ]:
40.62000

[ LogP ]:
4.27230

[ Index of Refraction ]:
1.519

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: CL5200000

CHEMICAL NAME :: 5-alpha-4-Azaandrostane-17-beta-carboxamide, N,N-diethyl-4-methyl-3-oxo-

CAS REGISTRY NUMBER :: 73671-86-0

LAST UPDATED :: 199612

DATA ITEMS CITED :: 3

MOLECULAR FORMULA :: C24-H40-N2-O2

MOLECULAR WEIGHT :: 388.66

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Subcutaneous

DOSE :: 2100 mg/kg

SEX/DURATION :: male 14 day(s) pre-mating

TOXIC EFFECTS :: Reproductive - Paternal Effects - testes, epididymis, sperm duct

REFERENCE :: PSEBAA Proceedings of the Society for Experimental Biology and Medicine. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1903/04- Volume(issue)/page/year: 169,67,1982

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Subcutaneous

DOSE :: 700 mg/kg

SEX/DURATION :: male 14 day(s) pre-mating

TOXIC EFFECTS :: Reproductive - Paternal Effects - prostate, seminal vesicle, Cowper's gland, accessory glands

REFERENCE :: PSEBAA Proceedings of the Society for Experimental Biology and Medicine. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1903/04- Volume(issue)/page/year: 169,67,1982

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Subcutaneous

DOSE :: 135 mg/kg

SEX/DURATION :: female 13-21 day(s) after conception

TOXIC EFFECTS :: Reproductive - Specific Developmental Abnormalities - urogenital system

REFERENCE :: PSEBAA Proceedings of the Society for Experimental Biology and Medicine. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1903/04- Volume(issue)/page/year: 169,67,1982