4-Bromophenethylamine

Names

[ Name ]:
4-Bromophenethylamine

[Synonym ]:
2-(4-bromophenyl)ethan-1-amine
Benzeneethanamine, 4-bromo-
EINECS 277-636-2
2-(4-Bromophenyl)ethanamine
4-Bromophenethylamine
MFCD00008189
2-(4-Bromophenyl)ethylamine

Biological Activity

[Description]:

ZH8651 is an agonist of TAAR1 which can activate both Gs and Gq signal pathway. ZH8651 can used in study schizophrenia[1].

[Related Catalog]:

Research Areas >> Neurological Disease

[References]

[1]. Shang P, et al. Structural and signaling mechanisms of TAAR1 enabled preferential agonist design. Cell. 2023 Nov 22;186(24):5347-5362.e24.

Chemical & Physical Properties

[ Density]:
1.4±0.1 g/cm3

[ Boiling Point ]:
271.3±0.0 °C at 760 mmHg

[ Molecular Formula ]:
C₈H₁₀BrN

[ Molecular Weight ]:
200.076

[ Flash Point ]:
113.1±20.4 °C

[ Exact Mass ]:
198.999649

[ PSA ]:
26.02000

[ LogP ]:
2.23

[ Vapour Pressure ]:
0.0±0.5 mmHg at 25°C

[ Index of Refraction ]:
1.576

MSDS

Click to get detail MSDS

Safety Information

[ Symbol ]:

GHS05

[ Signal Word ]:
Danger

[ Hazard Statements ]:
H314

[ Precautionary Statements ]:
P280-P305 + P351 + P338-P310

[ Personal Protective Equipment ]:
Faceshields;full-face respirator (US);Gloves;Goggles;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter

[ Hazard Codes ]:
C:Corrosive;

[ Risk Phrases ]:
R34

[ Safety Phrases ]:
S26-S36/37/39-S45

[ RIDADR ]:
UN 2735

[ WGK Germany ]:
3

[ Packaging Group ]:
III

[ Hazard Class ]:
8.0

[ HS Code ]:
2921499090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Customs

[ HS Code ]: 2921499090

[ Summary ]:
2921499090 other aromatic monoamines and their derivatives; salts thereof VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:30.0%

Articles

A facile one-pot preparation of alkyl aminoaryl sulfides for the synthesis of GW7647 as an agonist of peroxisome proliferator-activated receptor alpha.

J. Org. Chem. 71 , 5781, (2006)

We have developed two simple and high yielding one-pot syntheses of alkyl aminoaryl sulfides containing a series of four-steps: in situ protection of the free amine by reaction with a Grignard reagent...

Targeted LC-MS derivatization for aldehydes and carboxylic acids with a new derivatization agent 4-APEBA.

Anal. Bioanal. Chem 397 , 665-75, (2010)

Based on the template of a recently introduced derivatization reagent for aldehydes, 4-(2-(trimethylammonio)ethoxy)benzeneaminium dibromide (4-APC), a new derivatization agent was designed with additi...

Formation of pyrazinoisoquinoline ring system by the tandem amidoalkylation and N-acyliminium ion cyclization: An efficient synthesis of Praziquantel. Kim JH, et al.

Tetrahedron 54(26) , 7395-7400, (1998)