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8-Geranyloxypsoralen

Names

[ CAS No. ]:
7437-55-0

[ Name ]:
8-Geranyloxypsoralen

[Synonym ]:
9-((3,7-Dimethylocta-2,6-dien-1-yl)-oxy)-7H-furo[3,2-g]chromen-7-one
8-Geranyloxy psoralen
7H-Furo(3,2-g)(1)benzopyran-7-one, 9-((3,7-dimethyl-2,6-octadienyl)oxy)-
7H-Furo[3,2-g][1]benzopyran-7-one, 9-[[(2E)-3,7-dimethyl-2,6-octadien-1-yl]oxy]-
9-{[(2E)-3,7-Dimethyl-2,6-octadien-1-yl]oxy}-7H-furo[3,2-g]chromen-7-one

Biological Activity

[Description]:

8-Geranyloxypsoralen is a furanocoumarin isolated from grapefruit, acts as a potent inhibitor of P450 3A4 (CYP3A4) with an IC50 of 3.93 μM[1].

[Related Catalog]:

Signaling Pathways >> Metabolic Enzyme/Protease >> Cytochrome P450
Research Areas >> Others

[Target]

IC50: 3.93 μM (P450 3A4)[1]


[References]

[1]. Row EC, et al. Synthesis of 8-geranyloxypsoralen analogues and their evaluation as inhibitors of CYP3A4. Bioorg Med Chem. 2006 Jun 1;14(11):3865-71.

Chemical & Physical Properties

[ Density]:
1.2±0.1 g/cm3

[ Boiling Point ]:
503.7±50.0 °C at 760 mmHg

[ Molecular Formula ]:
C21H22O4

[ Molecular Weight ]:
338.397

[ Flash Point ]:
258.4±30.1 °C

[ Exact Mass ]:
338.151794

[ PSA ]:
52.58000

[ LogP ]:
5.85

[ Vapour Pressure ]:
0.0±1.3 mmHg at 25°C

[ Index of Refraction ]:
1.583

[ Storage condition ]:
2-8°C

Safety Information

[ Symbol ]:

GHS07

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H302-H317

[ Precautionary Statements ]:
P280

[ Hazard Codes ]:
Xn

[ Risk Phrases ]:
22-43

[ Safety Phrases ]:
36-37

[ RIDADR ]:
NONH for all modes of transport

Related Compounds