ML116

Names

[ Name ]:
ML116

[Synonym ]:
MFCD04535848
4-[4-(phenylmethyl)-1-piperidinyl]thieno[2,3-d]pyrimidine
Thieno[2,3-d]pyrimidine, 4-[4-(phenylmethyl)-1-piperidinyl]-
4-benzyl-1-{thieno[2,3-d]pyrimidin-4-yl}piperidine
4-(4-Benzyl-1-piperidinyl)thieno[2,3-d]pyrimidine

Biological Activity

[Description]:

A novel selective STAT3 inhibitor with IC50 of 4.2 uM, does not inhibit STAT1, STAT5, or NFkB signaling pathways (IC50>50 uM); inhibits transcription of the STAT3-regulated gene BCL3, sslectively induces loss of viability of breast cancer cell lines such as MDA-MB-468 cells.

[References]

References 1. Assi HH, et al. J Pharmacol Exp Ther. 2014 Jun;349(3):458-69. 2. Madoux F, et al. Probe Reports from the NIH Molecular Libraries Program [Internet]. View Related Products by Target STAT

Chemical & Physical Properties

[ Density]:
1.2±0.1 g/cm3

[ Boiling Point ]:
482.3±25.0 °C at 760 mmHg

[ Molecular Formula ]:
C₁₈H₁₉N₃S

[ Molecular Weight ]:
309.429

[ Flash Point ]:
245.5±23.2 °C

[ Exact Mass ]:
309.129974

[ LogP ]:
4.42

[ Vapour Pressure ]:
0.0±1.2 mmHg at 25°C

[ Index of Refraction ]:
1.663