Borate(1-),ammine(carboxylato)dihydro-, hydrogen, (T-4)- (9CI)

Names

[ Name ]:
Borate(1-),ammine(carboxylato)dihydro-, hydrogen, (T-4)- (9CI)

[Synonym ]:
carboxyborane ammonia complex
ammoniumboranecarboxylate
2-boronoglycine
AMMONIA-BORANECARBOXYLIC ACID
BOROGLYCINE
boranecarboxylicacid,ammoniumsalt

Chemical & Physical Properties

[ Molecular Formula ]:
CH₆BNO₂

[ Molecular Weight ]:
74.87480

[ Exact Mass ]:
75.04920

[ PSA ]:
40.54000

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: ED1160000

CHEMICAL NAME :: Boranecarboxylic acid, ammonium salt

CAS REGISTRY NUMBER :: 74861-59-9

LAST UPDATED :: 199712

DATA ITEMS CITED :: 3

MOLECULAR FORMULA :: C-H2-B-O2.H4-N

MOLECULAR WEIGHT :: 74.89

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: >1 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

MUTATION DATA

TYPE OF TEST :: Mutation test systems - not otherwise specified

TEST SYSTEM :: Rodent - mouse Ascites tumor

DOSE/DURATION :: 100 umol/L

REFERENCE :: JPMSAE Journal of Pharmaceutical Sciences. (American Pharmaceutical Assoc., 2215 Constitution Ave., NW, Washington, DC 20037) V.50- 1961- Volume(issue)/page/year: 74,755,1985

Safety Information

[ RTECS ]:
ED1160000

Articles

The antineoplastic activity of trimethylamine carboxyboranes and related esters and amides in murine and human tumor cell lines.

Anticancer Drugs 1 , 133, (1990)

Trimethylamine carboxyboranes including their esters and amides were shown to have antineoplastic activity in vivo against Ehrlich ascites carcinoma growth. The derivatization to the ester or amide di...

Antihyperlipidemic activity of amine cyanoboranes, amine carboxyboranes, and related compounds.

J. Pharm. Sci. 70 , 339, (1981)

A series of amine cyanoboranes and amine carboxyboranes were observed to be antihyperlipidemic agents in mice; i.e., they lowered serum cholesterol and triglyceride levels significantly. These compoun...

New compounds for neutron capture therapy (NCT) and their significance.

Strahlentherapie 160(12) , 764-70, (1984)

The significant advantage to be gained from combining the improved penetration of a scandium filtered beam with the reduced dose to normal tissues makes the development of 3rd generation compounds for...