K-777

Names

[ Name ]:
K-777

Biological Activity

[Description]:

K-777 is a potent and selective CCR4 antagonist that inhibits both CCL17 binding and CCL17-induced chemotaxis in Hut78 cells with IC50 of 57 and 8.9 nM respectively; induces CCR4 internalization, reduces cell surface CCR4.

[References]

References 1. Sato T, et al. Pharmacology. 2013;91(5-6):305-13. 2. Solari R, et al. Eur J Pharmacol. 2015 Sep 15;763(Pt B):169-77. View Related Products by Target Chemokine Receptor (CCR and CXCR)

Chemical & Physical Properties

[ Molecular Formula ]:
C₂₈H₃₂F₄IN₅

[ Molecular Weight ]:
641.5

Related Compounds

k-252a
k-ras(g12c) inhibitor 6
K-Ras ligand-Linker Conjugate 4
K-Ras ligand-Linker Conjugate 5
K 03861
K-975
N-(2-methoxyphenyl)-7-methyl-5-oxo-1-thioxo-4,5-dihydro-1H-thiazolo[3,4-a]quinazoline-3-carboxamide
4-((Cyclohexylamino)methyl)benzoic acid hydrochloride
1-[(2,4-Dichlorophenyl)methyl]-N-(1,1-dimethylethyl)-2-methyl-1H-indole-3-methanamine
2-Methoxy-6-(pyrazol-1-yl)-benzonitrile
1H-3-Benzazepin-7-ol, 8-chloro-2,3,4,5-tetrahydro-5-(3-iodophenyl)-3-methyl-, (S)-
(4-Methyl-tetrahydro-furan-2-yl)-methanol
1-[(2,3-Difluorophenyl)methyl]-2-methylpiperazine
N-(1-cyanocyclopentyl)-2-[4-(4-fluorobenzenesulfonyl)-1,4-diazepan-1-yl]acetamide
4,5,6,7-Tetrahydrobenzo[d]isoxazole-3-carbaldehyde
tert-Butyl-DL-alanine