Isobutane Residual Solvent Standard

MOLECULAR FORMULA :

C4-H10

MOLECULAR WEIGHT :

58.14

WISWESSER LINE NOTATION :

1Y1&1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :

LC50 - Lethal concentration, 50 percent kill

ROUTE OF EXPOSURE :

Inhalation

SPECIES OBSERVED :

Rodent - rat

DOSE/DURATION :

57 pph/15M

TOXIC EFFECTS :

Behavioral - tremor Behavioral - convulsions or effect on seizure threshold Lungs, Thorax, or Respiration - respiratory depression

REFERENCE :

HUTODJ Human Toxicology. (Macmillan Press Ltd., Houndmills, Basingstoke, Hants., RG 21 2XS, UK) V.1- 1981- Volume(issue)/page/year: 1,239,1982

TYPE OF TEST :

LCLo - Lowest published lethal concentration

ROUTE OF EXPOSURE :

Inhalation

SPECIES OBSERVED :

Rodent - mouse

DOSE/DURATION :

1041 gm/m3/2H

TOXIC EFFECTS :

Behavioral - excitement

REFERENCE :

JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 58,74,1936 *** REVIEWS *** TOXICOLOGY REVIEW FAZMAE Fortschritte der Arzneimittelforschung. Progress in Drug Research. (Birkhauser Boston, Inc., c/o Springer-Verlag New York, 44 Hartz Way, Secaucus, NJ 07094) V.1- 1959- Volume(issue)/page/year: 18,365,1974 *** OCCUPATIONAL EXPOSURE LIMITS *** OEL-GERMANY:TWA 1000 ppm (2350 mg/m3) JAN 1993 OEL-SWITZERLAND:TWA 800 ppm (1900 mg/m3) JAN 1993 OEL-UNITED KINGDOM:TWA 600 ppm (1430 mg/m3);STEL 750 ppm JAN 1993 OEL IN BULGARIA, COLOMBIA, JORDAN, KOREA check ACGIH TLV OEL IN NEW ZEALAND, SINGAPORE, VIETNAM check ACGIH TLV *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 81851 No. of Facilities: 118992 (estimated) No. of Industries: 360 No. of Occupations: 199 No. of Employees: 1193478 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - 81851 No. of Facilities: 110810 (estimated) No. of Industries: 377 No. of Occupations: 233 No. of Employees: 1795168 (estimated) No. of Female Employees: 556159 (estimated)