1,2-Dibromocyclopentene

Names

[ Name ]:
1,2-Dibromocyclopentene

[Synonym ]:
1,2-dibromocyclopent-1-ene
Cyclopentene, 1,2-dibromo-
1,2-Dibromocyclopentene
1,2-dibromocyclopenten
1,2-Dibrom-cyclopenten
1,2-dibromo-cyclopentene
MFCD00010246
1,2-bis(bromanyl)cyclopentene
1,2-dibromocyclopenetene

Chemical & Physical Properties

[ Density]:
2.1±0.1 g/cm3

[ Boiling Point ]:
219.9±0.0 °C at 760 mmHg

[ Molecular Formula ]:
C₅H₆Br₂

[ Molecular Weight ]:
225.909

[ Flash Point ]:
78.9±26.6 °C

[ Exact Mass ]:
223.883606

[ LogP ]:
3.22

[ Vapour Pressure ]:
0.2±0.4 mmHg at 25°C

[ Index of Refraction ]:
1.635

[ Storage condition ]:
2-8°C

MSDS

Click to get detail MSDS

Safety Information

[ Personal Protective Equipment ]:
Eyeshields;Gloves

[ Hazard Codes ]:
Xi: Irritant;

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
3

[ HS Code ]:
2903890090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Customs

[ HS Code ]: 2903890090

[ Summary ]:
2903890090. halogenated derivatives of cyclanic, cyclenic or cyclotherpenic hydrocarbons. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:5.5%. General tariff:30.0%

Articles

Selective mono- and 1,2-difunctionalisation of cyclopentene derivatives via Mg and Cu intermediates.

Chemistry 14 , 2499, (2008)

A single Br/Mg exchange of 1,2-dibromocyclopentene with iPrMgCl LiCl provides the corresponding beta-bromocyclopentenylmagnesium reagent, which can then be reacted with various electrophiles (yields: ...

The discovery of 6-[2-(5-chloro-2-{[(2,4-difluorophenyl)methyl]oxy}phenyl)-1-cyclopenten-1-yl]-2-pyridinecarboxylic acid, GW848687X, a potent and selective prostaglandin EP1 receptor antagonist for the treatment of inflammatory pain.

Bioorg. Med. Chem. Lett. 17(2) , 385-9, (2007)

The discovery of a series of selective EP1 receptor antagonists based on a 1,2-diarylcyclopentene template is described. After defining the structural requirements for EP1 potency and selectivity, het...