6-Bromopurine

Names

[ CAS No. ]:
767-69-1

[ Name ]:
6-Bromopurine

[Synonym ]:
Purine,6-bromo
6-bromo-9H-purine
7H-Purine, 6-bromo-
7H-Purine, 6-chloro-
6-Brom-purin
1H-purine, 6-bromo-
MFCD00022648
6-bromo-7(9)H-purine
1H-purine, 6-chloro-
1H-Purine,6-bromo
BROMOPURINE
BB-127E
6-Chloropurine
6-Bromopurine
EINECS 212-187-8
6-Chloro-1H-purine
9H-Purine,6-bromo
6-Bromo-1H-purine
9H-purine, 6-bromo-
6-BROMO PURINE

Chemical & Physical Properties

[ Density]:
1.7±0.1 g/cm3

[ Boiling Point ]:
449.6±25.0 °C at 760 mmHg

[ Melting Point ]:
>300ºC

[ Molecular Formula ]:
C₅H₃ClN₄

[ Molecular Weight ]:
154.557

[ Flash Point ]:
258.2±8.8 °C

[ Exact Mass ]:
154.004623

[ PSA ]:
54.46000

[ LogP ]:
0.13

[ Vapour Pressure ]:
0.0±1.1 mmHg at 25°C

[ Index of Refraction ]:
1.740

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: UO7513000

CHEMICAL NAME :: Purine, 6-bromo-

CAS REGISTRY NUMBER :: 767-69-1

LAST UPDATED :: 198502

DATA ITEMS CITED :: 1

MOLECULAR FORMULA :: C5-H3-Br-N4

MOLECULAR WEIGHT :: 199.03

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Parenteral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 323 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: JPMSAE Journal of Pharmaceutical Sciences. (American Pharmaceutical Assoc., 2215 Constitution Ave., NW, Washington, DC 20037) V.50- 1961- Volume(issue)/page/year: 71,618,1982

Safety Information

[ Symbol ]:

GHS07

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H315-H319-H335

[ Precautionary Statements ]:
P261-P305 + P351 + P338

[ Personal Protective Equipment ]:
dust mask type N95 (US);Eyeshields;Gloves

[ Hazard Codes ]:
Xi: Irritant;

[ Risk Phrases ]:
R36/37/38

[ Safety Phrases ]:
S26-S36

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
3.0

[ RTECS ]:
UO7513000

[ HS Code ]:
2933990090

Precursor & DownStream

Precursor

DownStream

Customs

[ HS Code ]: 2933990090

[ Summary ]:
2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

Articles

6-bromopurine nucleosides as reagents for nucleoside analogue synthesis.

J. Org. Chem. 66(25) , 8592-8, (2001)

Surprisingly facile direct substitution reactions with acetyl-protected 6-bromopurine nucleosides are described. Included in the series of bromonucleosides studied is the guanosine derivative N(2)-2',...

Chelator-accelerated one-pot 'click' labeling of small molecule tracers with 2-[¹⁸F]fluoroethyl azide.

Molecules 18(5) , 5335-47, (2013)

2-[¹⁸F]Fluoroethyl azide ([¹⁸F]FEA) can readily be obtained by nucleophilic substitution of 2-azidoethyl-4-toluenesulfonate with [¹⁸F]fluoride (half-life 110 min), and has become widely used as a reag...

Comparison of some biologgical and biochemical properties of 6-bromopurine and 6-iodopurine.

Biochem. Pharmacol. 11 , 1017-24, (1962)