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MEGX (hydrochloride)

Names

[ CAS No. ]:
7729-94-4

[ Name ]:
MEGX (hydrochloride)

[Synonym ]:
N-Ethylglycinhydrochlorid
ethyl glycine hydrochloric acid salt
Glycine,N-ethyl-,hydrochloride
N-(2,6-dimethylphenyl)-2-ethylaminoacetamide hydrochloride
N-Aethyl-glycin-(2,6-dimethyl-anilid),Hydrochlorid
N-desethyl-lidocaine
2-(ethylamino)acetic acid hydrochloride
N-ethyl-glycine-(2,6-dimethyl-anilide),hydrochloride
monoethylglycine xylidide hydrochloride
N-ethyl glycine hydrochloride
N-Aethyl-glycin,Hydrochlorid
Lidocaine Impurity 1

Biological Activity

[Description]:

Monoethylglycinexylidide (MEGX) hydrochloride is a metabolite of Lidocain (HY-B0185) via oxidative N-deethylation of Lignocaine by liver cytochrome P-450 enzymes in the liver. Monoethylglycinexylidide has proven to be a highly sensitive indicator of hepatic dysfunction, especially in the field of liver transplantation[1][2].

[Related Catalog]:

Research Areas >> Inflammation/Immunology
Research Areas >> Metabolic Disease

[References]

[1]. Huang YS, et al. Measuring lidocaine metabolite--monoethylglycinexylidide as a quantitative index of hepatic function in adults with chronic hepatitis and cirrhosis. J Hepatol. 1993 Aug;19(1):140-7.  

[2]. Esen F, et al. Monoethylglycinexylidide (MEGX) as an early predictor of liver dysfunction in severe sepsis. Critical Care, 1997, 1(Suppl 1):P083.

Chemical & Physical Properties

[ Molecular Formula ]:
C12H19ClN2O

[ Molecular Weight ]:
242.75

[ Exact Mass ]:
242.11900

[ PSA ]:
44.62000

[ LogP ]:
3.69380

Synthetic Route

Click to get detail synthetic route

Related Compounds