5(8H)-Naphthacenone,10-[(3-amino-2,3,6-trideoxy-a-L-lyxo-hexopyranosyl)oxy]-7,9,10,12-tetrahydro-6,8,11-trihydroxy-8-(hydroxyacetyl)-12-imino-1-methoxy-,monohydrochloride, (8S,10S)- (9CI)
Names
[ CAS No. ]:
77331-69-2
[ Name ]:
5(8H)-Naphthacenone,10-[(3-amino-2,3,6-trideoxy-a-L-lyxo-hexopyranosyl)oxy]-7,9,10,12-tetrahydro-6,8,11-trihydroxy-8-(hydroxyacetyl)-12-imino-1-methoxy-,monohydrochloride, (8S,10S)- (9CI)
[Synonym ]:
5-iminodoxorubicin hydrochloride
5-iminodoxorubicin
Chemical & Physical Properties
[ Density]:
1.57g/cm3
[ Boiling Point ]:
907.6ºC at 760 mmHg
[ Molecular Formula ]:
C27H31ClN2O10
[ Molecular Weight ]:
578.99500
[ Flash Point ]:
502.7ºC
[ Exact Mass ]:
578.16700
[ PSA ]:
212.85000
[ LogP ]:
1.78850
[ Index of Refraction ]:
1.716
Toxicological Information
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- QI9457400
- CHEMICAL NAME :
- 5(8H)-Naphthacenone, 7,9,10,12-tetrahydro-10-((3-amino-2,3,6-trideoxy-alph a-L-lyxo- hexopyranosyl)oxy)-8-(hydroxyacetyl)-12-imino-1-metho xy-6,8,11-trihydroxy-, monohydrochloride, (8S-cis)-
- CAS REGISTRY NUMBER :
- 77331-69-2
- LAST UPDATED :
- 198508
- DATA ITEMS CITED :
- 2
- MOLECULAR FORMULA :
- C27-H30-N2-O10.Cl-H
- MOLECULAR WEIGHT :
- 579.05
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
MUTATION DATA
- TYPE OF TEST :
- Mutation test systems - not otherwise specified
- TEST SYSTEM :
- Rodent - mouse Leukocyte
- DOSE/DURATION :
- 2100 nmol/L
- REFERENCE :
- JMCMAR Journal of Medicinal Chemistry. (American Chemical Soc., Distribution Office Dept. 223, POB POB 57136, West End Stn., Washington, DC 20037) V.6- 1963- Volume(issue)/page/year: 24,669,1981