Chloroacetone
Names
[ CAS No. ]:
78-95-5
[ Name ]:
Chloroacetone
[Synonym ]:
Tonite
MFCD00000936
Chloro acetone
1-Chloroacetone
Chloropropanone
2-Propanone,1-chloro
Chloroacetone
Acetonyl chloride
Chloracetone
2-Propanone, 1-chloro-
1-chloro-propan-2-one
α-Chloroacetone
Monochloracetone
EINECS 201-161-1
1-chloropropanone
1-chloropropan-2-one
Chemical & Physical Properties
[ Density]:
1.1±0.1 g/cm3
[ Boiling Point ]:
120.0±8.0 °C at 760 mmHg
[ Melting Point ]:
-44.5 °C
[ Molecular Formula ]:
C3H5ClO
[ Molecular Weight ]:
92.524
[ Flash Point ]:
27.8±0.0 °C
[ Exact Mass ]:
92.002892
[ PSA ]:
17.07000
[ LogP ]:
0.43
[ Vapour Pressure ]:
15.5±0.2 mmHg at 25°C
[ Index of Refraction ]:
1.397
[ Stability ]:
Stable. Incompatible with strong oxidizing agents, strong bases. May discolour on exposure to light. STENCH.
[ Water Solubility ]:
124 g/L (20 ºC)
MSDS
Toxicological Information
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- UC0700000
- CHEMICAL NAME :
- 2-Propanone, 1-chloro-
- CAS REGISTRY NUMBER :
- 78-95-5
- BEILSTEIN REFERENCE NO. :
- 0605369
- LAST UPDATED :
- 199712
- DATA ITEMS CITED :
- 17
- MOLECULAR FORMULA :
- C3-H5-Cl-O
- MOLECULAR WEIGHT :
- 92.53
- WISWESSER LINE NOTATION :
- G1V1
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- LCLo - Lowest published lethal concentration
- ROUTE OF EXPOSURE :
- Inhalation
- SPECIES OBSERVED :
- Human
- DOSE/DURATION :
- 605 ppm/10M
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 100 mg/kg
- TOXIC EFFECTS :
- Behavioral - somnolence (general depressed activity) Behavioral - ataxia Skin and Appendages - hair
- TYPE OF TEST :
- LC50 - Lethal concentration, 50 percent kill
- ROUTE OF EXPOSURE :
- Inhalation
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 262 ppm/1H
- TOXIC EFFECTS :
- Behavioral - somnolence (general depressed activity) Behavioral - ataxia Skin and Appendages - hair
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 80 mg/kg
- TOXIC EFFECTS :
- Behavioral - altered sleep time (including change in righting reflex) Behavioral - tremor Behavioral - convulsions or effect on seizure threshold
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 127 mg/kg
- TOXIC EFFECTS :
- Behavioral - somnolence (general depressed activity) Behavioral - ataxia Skin and Appendages - hair
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 92 mg/kg
- TOXIC EFFECTS :
- Behavioral - altered sleep time (including change in righting reflex) Behavioral - tremor Behavioral - convulsions or effect on seizure threshold
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Administration onto the skin
- SPECIES OBSERVED :
- Rodent - rabbit
- DOSE/DURATION :
- 141 mg/kg
- TOXIC EFFECTS :
- Behavioral - somnolence (general depressed activity) Behavioral - ataxia Skin and Appendages - hair
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Administration onto the skin
- SPECIES OBSERVED :
- Rodent - guinea pig
- DOSE/DURATION :
- 100 uL/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 650 mg/kg/17D-I
- TOXIC EFFECTS :
- Gastrointestinal - changes in structure or function of salivary glands Gastrointestinal - gastritis Nutritional and Gross Metabolic - weight loss or decreased weight gain
MUTATION DATA
- TEST SYSTEM :
- Insect - Drosophila melanogaster
- DOSE/DURATION :
- 100 pph/6M
- REFERENCE :
- PREBA3 Proceedings of the Royal Society of Edinburgh, Section B. (Edinburgh, Scotland, UK) V.61-74, 1943-74. Volume(issue)/page/year: 62,284,1946/1947 *** REVIEWS *** ACGIH TLV-CL 3.8 mg/m3 (1 ppm) (skin) DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year: TLV/BEI,1997 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X5194 No. of Facilities: 21 (estimated) No. of Industries: 1 No. of Occupations: 5 No. of Employees: 4354 (estimated) No. of Female Employees: 729 (estimated)
Safety Information
[ Symbol ]:
GHS02, GHS06, GHS09
[ Signal Word ]:
Danger
[ Hazard Statements ]:
H226-H301-H310 + H330-H315-H319-H335-H410
[ Precautionary Statements ]:
P260-P273-P280-P284-P301 + P310-P302 + P350
[ Personal Protective Equipment ]:
Eyeshields;Faceshields;full-face respirator (US);Gloves;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter
[ Hazard Codes ]:
T+:Verytoxic;N:Dangerous for the environment;
[ Risk Phrases ]:
R10;R24/25;R26;R36/37/38;R50/53
[ Safety Phrases ]:
S16-S23-S36/37/39-S45-S60-S61-S38-S28A-S26
[ RIDADR ]:
UN 1695 6.1/PG 1
[ WGK Germany ]:
3
[ RTECS ]:
UC0700000
[ Packaging Group ]:
I
[ Hazard Class ]:
6.1
Synthetic Route
Precursor & DownStream
Precursor
DownStream
Articles
Molecules 17(8) , 9335-47, (2012)
Successful implementation of ultrasound irradiation for the rapid synthesis of a novel series of 3-[1-(4-substituted-5-(aryldiazenyl)thiazol-2-yl)hydrazono)ethyl]-2H-chromen-2-ones 5a-h, via reactions...
[Reactions of 1-(X-benzoyl)-4-R-thiosemicarbazide with chloroacetone and omega-bromoacetophenone. VI. 4-(o-tolyl)-thiosemicarbazide of o-nitro - and p-nitrobenzoic acid].Ann. Univ. Mariae Curie. Sklodowska. Med. 51 , 195-202, (1996)
The reactions of 4-(o-tolyl)-thiosemicarbazide of o-nitro- and p-nitrobenzoic acid (Ik, l) with chloroacetone and omega-bromoacetophenone were investigated in: methanolic medium (method D); methanolic...
[Reactions of 1-(X-benzoyl)-4-R-thiosemicarbazide with chloroacetone and omega-bromoacetophenone. V. 4-(o-tolyl)-thiosemicarbazide of of o-chloro- and p-chlorobenzoic acid].Ann. Univ. Mariae Curie. Sklodowska. Med. 51 , 185-93, (1996)
The reactions of 4-(o-tolyl)-thiosemicarbazide of o-chloro- and p-chlorobenzoic acid (Ii, j) with chloroacetone and omega-bromoacetophenone were investigated in: methanolic medium (method D); methanol...