AZ-2

Names

[ Name ]:
AZ-2

Biological Activity

[Description]:

AZ-2 is a small molecule inducer of ABCA1 and apoE that act through indirect activation of the LXR pathway, shows purinergic receptor P2X7 antagonist activity; upregulates ABCA1 across multiple CNS cell types, including human astrocytes, pericytes, and microglia, through an indirect LXR mechanism and that also independently inhibit P2X7 receptor activity.

[References]

References 1. Fan J, et al. J Lipid Res. 2018 May;59(5):830-842. View Related Products by Target P2X Receptor

Chemical & Physical Properties

[ Molecular Formula ]:
C₂₄H₃₂ClN₃O₂

[ Molecular Weight ]:
429.989

Related Compounds

AZ-242
USP25 and 28 inhibitor AZ-2
trans-1.4-Bis-(o-methoxycarbonylbenzoyl)-tetra-az-2-en
Benzeneacetonitrile,4-chloro-a-(phenylmethylene)-, (aZ)-
desmethylnafoxidine aziridine
(Z)-11-HEXADECEN-1-YLACETATE
4-((Cyclohexylamino)methyl)benzoic acid hydrochloride
1-[(2,4-Dichlorophenyl)methyl]-N-(1,1-dimethylethyl)-2-methyl-1H-indole-3-methanamine
2-Methoxy-6-(pyrazol-1-yl)-benzonitrile
1H-3-Benzazepin-7-ol, 8-chloro-2,3,4,5-tetrahydro-5-(3-iodophenyl)-3-methyl-, (S)-
1-(4-Ethylcyclohexyl)-2,2-difluorocyclopropan-1-amine
(4-Methyl-tetrahydro-furan-2-yl)-methanol
N-(1-cyanocyclopentyl)-2-[4-(4-fluorobenzenesulfonyl)-1,4-diazepan-1-yl]acetamide
2-(5-Fluoro-2-methylphenyl)propanal
4,5,6,7-Tetrahydrobenzo[d]isoxazole-3-carbaldehyde
tert-Butyl-DL-alanine