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2'-Ethyl Simvastatin

Names

[ CAS No. ]:
79902-42-4

[ Name ]:
2'-Ethyl Simvastatin

[Synonym ]:
[1S-(1α,3α,7β,8β(2S*,4S*)8aβ)]-1,2,3,7,8,8a-hexahydro-3,7-dimethyl-8-[2-(tetrahydro-4-hydroxy-6-oxo-2H-pyran-2-yl)ethyl]-1-naphthalenyl 2-methylpropionate
zocor
Isobutyric acid (1S,3R,7S,8S,8aR)-8-[2-((2R,4R)-4-hydroxy-6-oxo-tetrahydro-pyran-2-yl)-ethyl]-3,7-dimethyl-1,2,3,7,8,8a-hexahydro-naphthalen-1-yl ester

Biological Activity

[Description]:

2'-Ethyl Simvastatin (compound 6) is a Mevinolin analog, with HMG-CoA reductase inhibition[1].

[Related Catalog]:

Research Areas >> Cancer
Research Areas >> Cardiovascular Disease
Signaling Pathways >> Metabolic Enzyme/Protease >> HMG-CoA Reductase (HMGCR)

[Target]

HMG-CoA reductase[1]


[References]

[1]. AGGARWAL, D., et al. A quantitative structure-activity relationship study of 3-hydroxy-3methylglutaryl-coenzyme A reductase inhibitors. Journal of Pharmacobio-Dynamics, 1988;11(9), 591–599.

Chemical & Physical Properties

[ Molecular Formula ]:
C23H34O5

[ Molecular Weight ]:
390.51300

[ Exact Mass ]:
390.24100

[ PSA ]:
72.83000

[ LogP ]:
3.80540

Related Compounds