Transglutaminase

[Description]:

Transglutaminase is an enzyme that forms crosslinks between protein molecules. Transglutaminase catalyses the formation of an isopeptide bond between the group of γ-carboxamides of glutamine residues and the first-order ε-amine groups of different compounds. Transglutaminase is involved in many physiological processes, including coagulation, antibacterial immune reactions and photosynthesis[1].

[Related Catalog]:

Research Areas >> Infection

Signaling Pathways >> Others >> Others

Research Areas >> Inflammation/Immunology

[In Vitro]

Transglutaminase activity can be increased by Co2+, Ba2+ and K+[1]. Microbial transglutaminases are inhibited by Zn2+, Cu2+, Hg2+ and Pb2+ ions which bind to the thiol group of cysteine in the active centre[1].

[ Molecular Formula ]:
C₂₇H₄₄O₃H₂O

[ Appearance of Characters ]:
lyophilized powder

[ Storage condition ]:
−20°C

[ Water Solubility ]:
H2O: soluble1.0mg/mL, clear

[ Personal Protective Equipment ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ Hazard Codes ]:
Xi

[ Risk Phrases ]:
36/37/38

[ Safety Phrases ]:
22-24/25-26

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
1

[ RTECS ]:
MA2370000

Glycation and transglutaminase mediated glycosylation of fish gelatin peptides with glucosamine enhance bioactivity.

Food Chem. 142 , 285-93, (2014)

A mixture of novel glycopeptides from glycosylation between cold water fish skin gelatin hydrolysates and glucosamine (GlcN) via transglutaminase (TGase), as well as glycation between fish gelatin hyd...

Inhibition of transglutaminase 2, a novel target for pulmonary fibrosis, by two small electrophilic molecules.

Am. J. Respir. Cell. Mol. Biol. 50(4) , 737-47, (2014)

Idiopathic pulmonary fibrosis (IPF) is characterized by progressive fibrotic destruction of normal lung architecture. Due to a lack of effective treatment options, new treatment approaches are needed....

Transglutaminase 2 interacts with syndecan-4 and CD44 at the surface of human macrophages to promote removal of apoptotic cells.

Biochim. Biophys. Acta 1853(1) , 201-12, (2015)

Tissue transglutaminase (TG2) is a multifunctional protein cross-linking enzyme that has been implicated in apoptotic cell clearance but is also important in many other cell functions including cell a...

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