C8, HUMAN

[ Storage condition ]:
−70°C

[ Hazard Codes ]:
B

[ RIDADR ]:
NONH for all modes of transport

Structure of human C8 protein provides mechanistic insight into membrane pore formation by complement.

J. Biol. Chem. 286 , 17585-17592, (2011)

C8 is one of five complement proteins that assemble on bacterial membranes to form the lethal pore-like "membrane attack complex" (MAC) of complement. The MAC consists of one C5b, C6, C7, and C8 and 1...

Structure of human complement C8, a precursor to membrane attack.

J. Mol. Biol. 405 , 325-330, (2011)

Complement component C8 plays a pivotal role in the formation of the membrane attack complex (MAC), an important antibacterial immune effector. C8 initiates membrane penetration and coordinates MAC po...

Functional studies of the MACPF domain of human complement protein C8alpha reveal sites for simultaneous binding of C8beta, C8gamma, and C9.

Biochemistry 45 , 5290-5296, (2006)

Human C8 is one of five components of the membrane attack complex of complement (MAC). It contains three subunits (C8alpha, C8beta, C8gamma) arranged as a disulfide-linked C8alpha-gamma dimer that is ...

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