TOPOISOMERASE I

[ Appearance of Characters ]:
buffered aqueous glycerol solution

[ Storage condition ]:
−70°C

[ Personal Protective Equipment ]:
Eyeshields;Gloves;half-mask respirator (US);multi-purpose combination respirator cartridge (US)

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
3

Transcription forms and remodels supercoiling domains unfolding large-scale chromatin structures.

Nat. Struct. Mol. Biol. 20(3) , 387-95, (2013)

DNA supercoiling is an inherent consequence of twisting DNA and is critical for regulating gene expression and DNA replication. However, DNA supercoiling at a genomic scale in human cells is uncharact...

A rapid and sensitive assay for DNA-protein covalent complexes in living cells.

Nucleic Acids Res. 41(9) , e104, (2013)

A number of proteins form covalent bonds with DNA as obligatory transient intermediates in normal nuclear transactions. Drugs that trap these complexes have proven to be potent therapeutics in both ca...

New insights into DNA-binding by type IIA topoisomerases.

Curr. Opin. Struct. Biol. 23(1) , 125-33, (2013)

Type IIA topoisomerases catalyze the passage of two DNA duplexes across each other to resolve the entanglements and coiling of cellular DNA. The ability of these enzymes to interact simultaneously but...

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