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Sancycline

Names

[ CAS No. ]:
808-26-4

[ Name ]:
Sancycline

[Synonym ]:
2-Naphthacenecarboxamide, 4-(dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,10,12,12a-tetrahydroxy-1,11-dioxo-, (4S,4aS,5aR,12aS)-
GS 2147
6-Demethyl-6-deoxytetracycline
6-demethyl-6-deoxy-tetracycline
6-deoxi-6-demethyl-tetracycline
Bonomycin
Sancycline
(4S,4aS,5aR,12aS)-4-(Dimethylamino)-3,10,12,12a-tetrahydroxy-1,11-dioxo-1,4,4a,5,5a,6,11,12a-octahydro-2-tetracenecarboxamide
Norcycline
(4S,4aS,5aR,12aS)-4-(Dimethylamino)-3,10,12,12a-tetrahydroxy-1,11-dioxo-1,4,4a,5,5a,6,11,12a-octahydrotetracene-2-carboxamide

Biological Activity

[Description]:

Sancycline is a rare semi-synthetic tetracycline prepared by hydrogenolysis of the chloro and benzylic hydroxy moieties of Declomycin。Target:Like other tetracyclines, sancycline acts by reversibly binding to the 30S ribosomal subunit and inhibiting protein translation by blocking entry of aminoacyl-tRNA into the ribosome A site.

[Related Catalog]:

Signaling Pathways >> Anti-infection >> Bacterial
Research Areas >> Infection

[Related Small Molecules]

Puromycin 2HCl | Geneticin | Tunicamycin | Hygromycin B | Salinomycin | Avibactam sodium | Neomycin sulfate | Vaborbactam | Methicillin SodiuM | Rifampicin | Metronidazole | Carbenicillin disodium | Ceftazidime | Eravacycline dihydrochloride | cefotaxime sodium

Chemical & Physical Properties

[ Density]:
1.6±0.1 g/cm3

[ Boiling Point ]:
750.9±60.0 °C at 760 mmHg

[ Melting Point ]:
224-228ºC (dec)

[ Molecular Formula ]:
C21H22N2O7

[ Molecular Weight ]:
414.409

[ Flash Point ]:
407.9±32.9 °C

[ Exact Mass ]:
414.142700

[ PSA ]:
161.39000

[ LogP ]:
-0.67

[ Vapour Pressure ]:
0.0±2.6 mmHg at 25°C

[ Index of Refraction ]:
1.735

[ Storage condition ]:
2-8℃

Precursor & DownStream

Precursor

DownStream

Related Compounds