Atomoxetine Hydrochloride

Names

[ Name ]:
Atomoxetine Hydrochloride

[Synonym ]:
Atomoxetine HCL
benzenepropanamine, N-methyl-γ-(2-methylphenoxy)-, (γR)-, hydrochloride
(gR)-N-Methyl-g-(2-methylphenoxy)benzenepropanamine Hydrochloride
(3R)-N-méthyl-3-(2-méthylphénoxy)-3-phénylpropan-1-amine chlorhydrate
MFCD06410992
(3R)-N-Methyl-3-(2-methylphenoxy)-3-phenylpropan-1-amine hydrochloride (1:1)
Atomoxetine hydrochloride
EINECS 200-659-6
(3R)-N-methyl-3-(2-methylphenoxy)-3-phenylpropan-1-amine hydrochloride
(3R)-N-Methyl-3-(2-methylphenoxy)-3-phenylpropan-1-aminhydrochlorid
(3R)-N-Methyl-3-(2-methylphenoxy)-3-phenyl-1-propanamine hydrochloride (1:1)
Benzenepropanamine, N-methyl-γ-(2-methylphenoxy)-, (γR)-, hydrochloride (1:1)
Atomoxetine (hydrochloride)

Biological Activity

[Description]:

Atomoxetine Hcl(LY 139603; Tomoxetine Hcl) is a potent and selective noradrenalin re-uptake inhibitor (Ki values are 5, 77 and 1451 nM for inhibition of radioligand binding to human NET, SERT and DAT respectively). IC50 value: 5 nM (Ki for human NET)Target: NETAtomoxetine displays minimal affinity for a range of other neurotransmitter receptors and transporters (Ki > 1 μM). Atomoxetine is antidepressant and a commonly used non-stimulant treatment for Attention deficit hyperactivity disorder (ADHD).

[Related Catalog]:

Signaling Pathways >> Others >> Others

Research Areas >> Neurological Disease

[References]

[1]. McAfee AT, Landon J, Jones M, et al. A cohort study of the risk of seizures in a pediatric population treated with atomoxetine or stimulant medications. Pharmacoepidemiol Drug Saf. 2012 Dec 26.

[2]. Turner M, Wilding E, Cassidy E, Dommett EJ. Effects of atomoxetine on locomotor activity and impulsivity in the spontaneously hypertensive rat. Behav Brain Res. 2012 Dec 22;243C:28-37.

[3]. Bymaster FP, Katner JS, Nelson DL et al. Atomoxetine increases extracellular levels of norepinephrine and dopamine in prefrontal cortex of rat: a potential mechanism for efficacy in attention deficit/hyperactivity disorder. Neuropsychopharmacology. 2002 N

[4]. Owens MJ, Morgan WN, Plott SJ, Nemeroff CB. Neurotransmitter receptor and transporter binding profile of antidepressants and their metabolites. J Pharmacol Exp Ther. 1997 Dec;283(3):1305-22.

[5]. Atomoxetine

[Related Small Molecules]

Chemical & Physical Properties

[ Boiling Point ]:
389ºC at 760 mmHg

[ Melting Point ]:
167-169ºC

[ Molecular Formula ]:
C₁₇H₂₂ClNO

[ Molecular Weight ]:
291.816

[ Flash Point ]:
164.1ºC

[ Exact Mass ]:
291.138977

[ PSA ]:
21.26000

[ LogP ]:
4.91750

[ Storage condition ]:
2-8°C

MSDS

Click to get detail MSDS

Safety Information

[ Symbol ]:

GHS02, GHS06, GHS08

[ Signal Word ]:
Danger

[ Hazard Statements ]:
H225-H301 + H311 + H331-H370

[ Precautionary Statements ]:
P210-P260-P280-P301 + P310-P311

[ Personal Protective Equipment ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ Hazard Codes ]:
F,T

[ Risk Phrases ]:
11-23/24/25-39/23/24/25

[ Safety Phrases ]:
S22-S24/25

[ RIDADR ]:
UN1230 - class 3 - PG 2 - Methanol, solution

[ WGK Germany ]:
3

[ HS Code ]:
2922299090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Customs

[ HS Code ]: 2922299090

[ Summary ]:
2922299090. other amino-naphthols and other amino-phenols, other than those containing more than one kind of oxygen function, their ethers and esters; salts thereof. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%

Articles

Methylphenidate and atomoxetine inhibit social play behavior through prefrontal and subcortical limbic mechanisms in rats.

J. Neurosci. 35(1) , 161-9, (2015)

Positive social interactions during the juvenile and adolescent phases of life, in the form of social play behavior, are important for social and cognitive development. However, the neural mechanisms ...

Atomoxetine prevents dexamethasone-induced skeletal muscle atrophy in mice.

J. Pharmacol. Exp. Ther. 351(3) , 663-73, (2014)

Skeletal muscle atrophy remains a clinical problem in numerous pathologic conditions. β2-Adrenergic receptor agonists, such as formoterol, can induce mitochondrial biogenesis (MB) to prevent such atro...

Current pharmacotherapy of attention deficit hyperactivity disorder.

Drugs Today (Barc) 49(10) , 647-65, (2013)

Attention deficit hyperactivity disorder (ADHD) is a neurobehavioral developmental disorder in children and adults characterized by a persistent pattern of impulsiveness, inattention and hyperactivity...