2,6-diaminotoluene

Names

[ CAS No. ]:
823-40-5

[ Name ]:
2,6-diaminotoluene

[Synonym ]:
2-Methyl-m-phenylenediamine
2-Methyl-1,3-benzenediamine
2,6-toluenediamine
MFCD00007800
2,6-diaminotoluene
2,6-Tolylenediamine
EINECS 212-513-9
1,3-Benzenediamine, 2-methyl-
2-methylbenzene-1,3-diamine

Chemical & Physical Properties

[ Density]:
1.1±0.1 g/cm3

[ Boiling Point ]:
284.2±20.0 °C at 760 mmHg

[ Melting Point ]:
104-106 °C(lit.)

[ Molecular Formula ]:
C₇H₁₀N₂

[ Molecular Weight ]:
122.168

[ Flash Point ]:
148.3±21.3 °C

[ Exact Mass ]:
122.084396

[ PSA ]:
52.04000

[ LogP ]:
0.15

[ Vapour Pressure ]:
0.0±0.6 mmHg at 25°C

[ Index of Refraction ]:
1.636

[ Stability ]:
Stable. Combustible. Incompatible with strong oxidizing agents, strong acids.

[ Water Solubility ]:
60 g/L (15 ºC)

MSDS

Click to get detail MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: XS9750000

CHEMICAL NAME :: Toluene-2,6-diamine

CAS REGISTRY NUMBER :: 823-40-5

BEILSTEIN REFERENCE NO. :: 2079476

LAST UPDATED :: 199710

DATA ITEMS CITED :: 12

MOLECULAR FORMULA :: C7-H10-N2

MOLECULAR WEIGHT :: 122.19

WISWESSER LINE NOTATION :: ZR CZ B1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: Micronucleus test

TYPE OF TEST :: DNA inhibition

MUTATION DATA

TYPE OF TEST :: Cytogenetic analysis

TEST SYSTEM :: Rodent - hamster Ovary

DOSE/DURATION :: 10 mmol/L

REFERENCE :: MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 265,45,1992

Safety Information

[ Symbol ]:

GHS07, GHS08, GHS09

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H302 + H312-H317-H341-H411

[ Precautionary Statements ]:
P273-P280

[ Personal Protective Equipment ]:
dust mask type N95 (US);Eyeshields;Faceshields;Gloves

[ Hazard Codes ]:
Xn:Harmful;N:Dangerousfortheenvironment;

[ Risk Phrases ]:
R21/22;R40;R43;R50/53

[ Safety Phrases ]:
S24-S36/37-S61

[ RIDADR ]:
UN 3077 9/PG 3

[ WGK Germany ]:
3

[ RTECS ]:
XS9750000

[ Packaging Group ]:
III

[ Hazard Class ]:
6.1

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Articles

Biological monitoring as a valid tool to assess occupational exposure to mixtures of 2,4-:2,6-toluene diisocyanate.

Med. Lav. 103(5) , 361-71, (2012)

Despite its advantages over environmental monitoring, biological monitoring of exposure to 2,4-:2,6-toluene diisocyanate (TDI) mixtures is still underused. The present study was designed in order to e...

Air exposure assessment of TDI and biological monitoring of TDA in urine in workers in polyurethane foam industry.

Occup. Environ. Med. 69(2) , 93-8, (2012)

Toluene diisocyanate (TDI) is used in the manufacturing process of polyurethane (PU) foams and is a potent inducer of occupational asthma. The objective of this study was to evaluate the correlation b...

Improvement in the GC-MS method for determining urinary toluene-diamine and its application to the biological monitoring of workers exposed to toluene-diisocyanate.

Int. Arch. Occup. Environ. Health 78(6) , 459-66, (2005)

To develop a simple and sensitive GC-MS method for determining toluene-diamine (TDA) in urine and to apply the method for biological monitoring of workers exposed to toluene-diisocyanate (TDI).After a...