STAT3 inhibitor C188

Names

[ Name ]:
STAT3 inhibitor C188

Biological Activity

[Description]:

A potent, selective STAT3 inhibitor that blocks STAT3 binding to its phosphopeptide ligand (IC50=20 uM) and inhibits IL-6-mediated phosphorylation of STAT3; inhibits nuclear translocation of phosphorylated Stat3 with IC50 of 39 uM, induces apoptosis preferentially of breast cancer cell lines with constitutive Stat3 activation.

[References]

References 1. Xu X, et al. PLoS One. 2009;4(3):e4783. View Related Products by Target STAT

Chemical & Physical Properties

[ Molecular Formula ]:
C₁₉H₁₅NO₇S₂

[ Molecular Weight ]:
433.449

Related Compounds

STAT3 inhibitor N4
BP-1-102
Stattic
STAT3-SH2 domain inhibitor 1
STAT3 inhibitor 3
STAT3-IN-8
4-((Cyclohexylamino)methyl)benzoic acid hydrochloride
1-[(2,4-Dichlorophenyl)methyl]-N-(1,1-dimethylethyl)-2-methyl-1H-indole-3-methanamine
(E)-3-(furan-3-yl)-N-((4-methoxytetrahydro-2H-thiopyran-4-yl)methyl)acrylamide
N-((1-(5-fluoropyrimidin-2-yl)piperidin-4-yl)methyl)benzo[c][1,2,5]thiadiazole-4-sulfonamide
2-Methoxy-6-(pyrazol-1-yl)-benzonitrile
(3,4-Diethoxyphenyl)(3-(methylsulfonyl)pyrrolidin-1-yl)methanone
1H-3-Benzazepin-7-ol, 8-chloro-2,3,4,5-tetrahydro-5-(3-iodophenyl)-3-methyl-, (S)-
1-(4-Amino-1,2,3,4-tetrahydroisoquinolin-2-yl)ethan-1-one
(4-Methyl-tetrahydro-furan-2-yl)-methanol
N-(1-cyanocyclopentyl)-2-[4-(4-fluorobenzenesulfonyl)-1,4-diazepan-1-yl]acetamide