DCPIB

Names

[ Name ]:
DCPIB

[Synonym ]:
dcpib
hms3268c07

Biological Activity

[Description]:

DCPIB is a selective, reversible and potent inhibitor of volume-regulated anion channels (VRAC), voltage-dependently activates potassium channels TREK1 and TRAAK, inhibits TRESK, TASK1 and TASK3 (IC50s, 0.14, 0.95, 50.72 μM, respectively)[1]. DCPIB is also a selective blocker of swelling-induced chloride current (ICl,swell), with an IC50 of 4.1 μM in CPAE cells[2].

[Related Catalog]:

Signaling Pathways >> Membrane Transporter/Ion Channel >> Chloride Channel

Research Areas >> Neurological Disease

Signaling Pathways >> Membrane Transporter/Ion Channel >> Potassium Channel

[Target]

IC50：0.14 μM (TRESK), 0.95 μM (TASK1), 50.72 μM (TASK3)[1], 4.1 μM (ICl,swell, CPAE cells)[2]

[References]

[1]. Lv J, et al. DCPIB, an Inhibitor of Volume-Regulated Anion Channels, Distinctly Modulates K2P Channels. ACS Chem Neurosci. 2019 Apr 17.

[2]. Decher N, et al. DCPIB is a novel selective blocker of I(Cl,swell) and prevents swelling-induced shortening of guinea-pig atrial action potential duration. Br J Pharmacol. 2001 Dec;134(7):1467-79.

Chemical & Physical Properties

[ Density]:
1.263g/cm3

[ Boiling Point ]:
593.835ºC at 760 mmHg

[ Molecular Formula ]:
C₂₂H₂₈Cl₂O₄

[ Molecular Weight ]:
427.36

[ Flash Point ]:
312.94ºC

[ Exact Mass ]:
426.13600

[ PSA ]:
63.60000

[ LogP ]:
6.34260

[ Index of Refraction ]:
1.564

[ Storage condition ]:
2-8℃

DCPIB

Names

Biological Activity

Chemical & Physical Properties

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Related Compounds