4,4'-DDA

Names

[ CAS No. ]:
83-05-6

[ Name ]:
4,4'-DDA

[Synonym ]:
EINECS 201-451-8
MFCD00004248
Bis(4-chlorophenyl)acetic Acid

Chemical & Physical Properties

[ Density]:
1.373g/cm3

[ Boiling Point ]:
411.4ºC at 760 mmHg

[ Melting Point ]:
167-169ºC(lit.)

[ Molecular Formula ]:
C₁₄H₁₀Cl₂O₂

[ Molecular Weight ]:
281.13400

[ Flash Point ]:
202.6ºC

[ Exact Mass ]:
280.00600

[ PSA ]:
37.30000

[ LogP ]:
4.20990

[ Index of Refraction ]:
1.616

MSDS

Click to get detail MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: AF5475000

CHEMICAL NAME :: Acetic acid, bis(p-chlorophenyl)-

CAS REGISTRY NUMBER :: 83-05-6

BEILSTEIN REFERENCE NO. :: 1913593

LAST UPDATED :: 199706

DATA ITEMS CITED :: 8

MOLECULAR FORMULA :: C14-H10-Cl2-O2

MOLECULAR WEIGHT :: 281.14

WISWESSER LINE NOTATION :: QYVR DG&R DG

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 740 mg/kg

TOXIC EFFECTS :: Gastrointestinal - hypermotility, diarrhea Gastrointestinal - nausea or vomiting Liver - other changes

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 590 mg/kg

TOXIC EFFECTS :: Behavioral - hallucinations, distorted perceptions

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 250 mg/kg

SEX/DURATION :: female 15-19 day(s) after conception

TOXIC EFFECTS :: Reproductive - Specific Developmental Abnormalities - urogenital system

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intraperitoneal

DOSE :: 350 mg/kg

SEX/DURATION :: female 7 day(s) pre-mating

TOXIC EFFECTS :: Reproductive - Maternal Effects - uterus, cervix, vagina

TYPE OF TEST :: Sex chromosome loss and nondisjunction

MUTATION DATA

TYPE OF TEST :: Cytogenetic analysis

TEST SYSTEM :: Rodent - rat Cells - not otherwise specified

DOSE/DURATION :: 150 mg/L/24H (Continuous)

REFERENCE :: TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year: 22,355,1972

Safety Information

[ Symbol ]:

GHS07, GHS08

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H302 + H312 + H332-H351

[ Precautionary Statements ]:
P280

[ Personal Protective Equipment ]:
dust mask type N95 (US);Eyeshields;Gloves

[ Hazard Codes ]:
Xn: Harmful;

[ Risk Phrases ]:
R20/21/22

[ Safety Phrases ]:
7-22-36-45

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
3

[ RTECS ]:
AF5475000

[ HS Code ]:
2916399090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Customs

[ HS Code ]: 2916399090

[ Summary ]:
2916399090 other aromatic monocarboxylic acids, their anhydrides, halides, peroxides, peroxyacids and their derivatives VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:30.0%

Articles

Mitotane (1-(o-chlorophenyl)-1-(p-chlorophenyl)-2,2-dichloroethane) metabolism in perfusion studies with dog adrenal glands.

Drug Metab. Dispos. 15(2) , 267-9, (1987)

Oxidation at C-1 controls the cytotoxicity of 1,1-dichloro-2,2- bis(p-chlorophenyl)ethane by rabbit and human lung cells.

Drug Metab. Dispos. 23(5) , 595-9, (1995)

Isolated rabbit Clara cells and a transformed human bronchial epithelial cell line, BEAS-2B, were used to investigate the mechanism of cytotoxicity of 1,1-dichloro-2,2-bis(p-chlorophenyl)ethane (DDD),...

Development of an enzyme-linked immunosorbent assay for the quantification of DDA (2,2-bis(p-chlorophenyl) acetic acid) in urine.

Bull. Environ. Contam. Toxicol. 38(5) , 798-804, (1987)