5,6-DIHYDRO-BENZO[C]ACRIDINE-7-CARBOXYLIC ACID
Names
[ CAS No. ]:
83-93-2
[ Name ]:
5,6-DIHYDRO-BENZO[C]ACRIDINE-7-CARBOXYLIC ACID
[Synonym ]:
Tetrophan
Tetrofan
5,6-dihydrobenz<c>acridine-7-carboxylic acid
3,4-Dihydro-1,2-benzacridinic-5-carbonic acid
Chemical & Physical Properties
[ Density]:
1.336g/cm3
[ Boiling Point ]:
495.8ºC at 760 mmHg
[ Molecular Formula ]:
C18H13NO2
[ Molecular Weight ]:
275.30100
[ Flash Point ]:
253.7ºC
[ Exact Mass ]:
275.09500
[ PSA ]:
50.19000
[ LogP ]:
3.69860
[ Index of Refraction ]:
1.719
Toxicological Information
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- CU3350000
- CHEMICAL NAME :
- Benz(c)acridine-7-carboxylic acid, 5,6-dihydro-
- CAS REGISTRY NUMBER :
- 83-93-2
- BEILSTEIN REFERENCE NO. :
- 0256492
- LAST UPDATED :
- 199709
- DATA ITEMS CITED :
- 3
- MOLECULAR FORMULA :
- C18-H13-N-O2
- MOLECULAR WEIGHT :
- 275.32
- WISWESSER LINE NOTATION :
- T D6 C666 BN&T&&J MVQ
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 760 mg/kg
- TOXIC EFFECTS :
- Behavioral - somnolence (general depressed activity) Behavioral - convulsions or effect on seizure threshold Behavioral - ataxia
- REFERENCE :
- JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 113,27,1955
- TYPE OF TEST :
- LDLo - Lowest published lethal dose
- ROUTE OF EXPOSURE :
- Unreported
- SPECIES OBSERVED :
- Mammal - cat
- DOSE/DURATION :
- 40 mg/kg
- TOXIC EFFECTS :
- Vascular - BP lowering not characterized in autonomic section
- REFERENCE :
- JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 113,27,1955
- TYPE OF TEST :
- LDLo - Lowest published lethal dose
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Rodent - rabbit
- DOSE/DURATION :
- 40 mg/kg
- TOXIC EFFECTS :
- Behavioral - tetany Cardiac - other changes Lungs, Thorax, or Respiration - dyspnea
- REFERENCE :
- JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 113,371,1955
Safety Information
[ HS Code ]:
2933990090
Synthetic Route
Precursor & DownStream
Precursor
DownStream
Customs
[ HS Code ]: 2933990090
[ Summary ]:
2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%