Hydroxy-alpha-sanshool

Names

[ Name ]:
Hydroxy-alpha-sanshool

[Synonym ]:
(2E,6Z,8E,10E)-N-(2-HYDROXY-2-METHYL-PROPYL)DODECA-2,6,8,10-TETRAENAMIDE
(2E,6Z,8E,10E)-N-(2-hydroxy-2-methylpropyl)dodeca-2,6,8,10-tetraenamide

Biological Activity

[Description]:

Hydroxy-α-sanshool is an alkylamide isolated from pepper, acts as a TRPA1 covalent and TRPV1 non-covalent agonist, with EC50s of 69 and 1.1 µM, respectively[1].

[Related Catalog]:

Signaling Pathways >> Membrane Transporter/Ion Channel >> TRP Channel

Research Areas >> Neurological Disease

[Target]

EC50: 69 µM (TRPA1), 1.1 µM (TRPV1)[1]

[References]

[1]. Koo JY, et al. Compounds from Sichuan and Melegueta peppers activate, covalently and non-covalently, TRPA1 and TRPV1 channels. Br J Pharmacol. 2009 Aug;157(8):1398-409.

Chemical & Physical Properties

[ Density]:
0.973 g/cm3

[ Boiling Point ]:
471.5±45.0℃ at 760 mmHg

[ Molecular Formula ]:
C₁₆H₂₅NO₂

[ Molecular Weight ]:
263.37500

[ Exact Mass ]:
263.18900

[ PSA ]:
49.33000

[ LogP ]:
3.28930

[ Storage condition ]:
2-8℃

Safety Information

[ HS Code ]:
2924199090

Customs

[ HS Code ]: 2924199090

[ Summary ]:
2924199090. other acyclic amides (including acyclic carbamates) and their derivatives; salts thereof. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%