LDN-76070

Names

[ Name ]:
LDN-76070

Biological Activity

[Description]:

LDN-76070 is a novel potent SMN2 modulator (EC50=8.3 uM; Emax 186%), increases SMN protein in spinal cord and brain in mice (5 mg/kg).

[References]

References 1. Rietz A, et al. J Med Chem. 2017 Jun 8;60(11):4594-4610. 2. Cherry JJ, et al. EMBO Mol Med. 2013 Jul;5(7):1103-18. View Related Products by Target SMN2 Modulator

Chemical & Physical Properties

[ Molecular Formula ]:
C₁₈H₁₇BrFNO₄

[ Molecular Weight ]:
410.239

Related Compounds

ldn-0096812
LDN-0088050
LDN-192960 2HCl
LDN 214117
LDN-211904
LDN-211904
4-((Cyclohexylamino)methyl)benzoic acid hydrochloride
1-[(2,4-Dichlorophenyl)methyl]-N-(1,1-dimethylethyl)-2-methyl-1H-indole-3-methanamine
2-Methoxy-6-(pyrazol-1-yl)-benzonitrile
1H-3-Benzazepin-7-ol, 8-chloro-2,3,4,5-tetrahydro-5-(3-iodophenyl)-3-methyl-, (S)-
2-(Benzyloxy)-4,6-bis(methoxymethoxy)benzoic acid
(4-Methyl-tetrahydro-furan-2-yl)-methanol
N-(1-cyanocyclopentyl)-2-[4-(4-fluorobenzenesulfonyl)-1,4-diazepan-1-yl]acetamide
4,5,6,7-Tetrahydrobenzo[d]isoxazole-3-carbaldehyde
tert-Butyl-DL-alanine
4-amino-N-[2-tert-butyl-1-(tetrahydro-2H-pyran-4-ylmethyl)-1H-benzimidazol-5-yl]-N-ethylbenzenesulfonamide