Naphthionic acid

Names

[ CAS No. ]:
84-86-6

[ Name ]:
Naphthionic acid

[Synonym ]:
Naphthionic acid
EINECS 201-567-9
MFCD00004027
4-Aminonaphthalene-1-sulfonic acid

Chemical & Physical Properties

[ Density]:
1.67

[ Boiling Point ]:
434ºC

[ Melting Point ]:
≥300 °C(lit.)

[ Molecular Formula ]:
C₁₀H₉NO₃S

[ Molecular Weight ]:
223.24800

[ Exact Mass ]:
223.03000

[ PSA ]:
88.77000

[ LogP ]:
3.33070

[ Index of Refraction ]:
1.713

MSDS

Click to get detail MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: QK1270000

CHEMICAL NAME :: 1-Naphthalenesulfonic acid, 4-amino-

CAS REGISTRY NUMBER :: 84-86-6

LAST UPDATED :: 199710

DATA ITEMS CITED :: 6

MOLECULAR FORMULA :: C10-H9-N-O3-S

MOLECULAR WEIGHT :: 223.26

WISWESSER LINE NOTATION :: L66J BZ ESWQ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD - Lethal dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: >7500 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information. Volume(issue)/page/year: OTS0533716

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 300 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information. Volume(issue)/page/year: AD277-689

Safety Information

[ Symbol ]:

GHS05

[ Signal Word ]:
Danger

[ Hazard Statements ]:
H314

[ Precautionary Statements ]:
P280-P305 + P351 + P338-P310

[ Personal Protective Equipment ]:
Eyeshields;Faceshields;full-face particle respirator type N100 (US);Gloves;respirator cartridge type N100 (US);type P1 (EN143) respirator filter;type P3 (EN 143) respirator cartridges

[ Hazard Codes ]:
C:Corrosive;

[ Risk Phrases ]:
R22;R34

[ Safety Phrases ]:
S26-S36/37/39-S45-S25

[ RIDADR ]:
UN 2585 8/PG 3

[ WGK Germany ]:
3

[ RTECS ]:
QK1270000

[ Packaging Group ]:
III

[ Hazard Class ]:
8

[ HS Code ]:
29214500

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Customs

[ HS Code ]: 2921450090

[ Summary ]:
2921450090 1-naphthylamine (α-naphthylamine), 2-naphthylamine (β-naphthylamine) and their derivatives; salts thereof。Supervision conditions:None。VAT:17.0%。Tax rebate rate:9.0%。MFN tariff:6.5%。General tariff:30.0%

Articles

Identification of [14C]carmoisine metabolites in bacterial suspension of rat faeces.

Food Addit. Contam. 7(1) , 1-7, (1990)

An in vitro system consisting of a bacterial suspension of human or rat faecal microflora brought about the biological reduction of the red azo dye [14C]carmoisine to 1-naphthyl-amine-4-sulphonic acid...

Synthetic organic food colouring agents and their degraded products: effects on human and rat cholinesterases.

Br. J. Biomed. Sci. 61(3) , 128-32, (2004)

Most synthetic coloured additives are carcinogenic; teratogenic and cause allergic reactions. In this study, the effects of synthetic azo dyes (sunset yellow FCF and carmoisine), as well as their degr...

Regiospecific O-methylation of naphthoic acids catalyzed by NcsB1, an O-methyltransferase involved in the biosynthesis of the enediyne antitumor antibiotic neocarzinostatin.

J. Biol. Chem. 283(21) , 14694-702, (2008)

Neocarzinostatin, a clinical anticancer drug, is the archetypal member of the chromoprotein family of enediyne antitumor antibiotics that are composed of a nonprotein chromophore and an apoprotein. Th...