JNJ-26070109

Names

[ Name ]:
JNJ-26070109

Biological Activity

[Description]:

A novel, potent, selective orally active CCK-2 receptor antagonist with pKi of 8.49 for hCCK2; displays >1200-fold selectivity over hCCK1 receptor; has oral EC50 of 1.5 and 0.26 uM in conscious rat and dog chronic gastric fistula models of pentagastrin-stimulated acid secretion, respectively; inhibits gastric acid secretion and prevents omeprazole-induced acid rebound in the rats.

[References]

References 1. Morton MF, et al. J Pharmacol Exp Ther. 2011 Jul;338(1):328-36. 2. Barrett TD, et al. Br J Pharmacol. 2012 Jul;166(5):1684-93. View Related Products by Target Cholecystokinin Receptor

Chemical & Physical Properties

[ Molecular Formula ]:
C₂₃H₁₇BrF₂N₄O₃S

[ Molecular Weight ]:
547.37

Related Compounds

JNJ 41876666
JNJ 10397049
JNJ-38893777 sulfate
JNJ-61803534
JNJ-7706621
JNJ-42253432
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2-Methoxy-6-(pyrazol-1-yl)-benzonitrile
2-(2-Amino-6-(difluoromethyl)-4-nitropyridin-3-yl)acetic acid
1H-3-Benzazepin-7-ol, 8-chloro-2,3,4,5-tetrahydro-5-(3-iodophenyl)-3-methyl-, (S)-
(4-Methyl-tetrahydro-furan-2-yl)-methanol
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4,5,6,7-Tetrahydrobenzo[d]isoxazole-3-carbaldehyde
tert-Butyl-DL-alanine
B-(4-Methoxy-8-quinolinyl)boronic acid