JNJ-26070109
Names
[ CAS No. ]:
844645-08-5
[ Name ]:
JNJ-26070109
Biological Activity
[Description]:
A novel, potent, selective orally active CCK-2 receptor antagonist with pKi of 8.49 for hCCK2; displays >1200-fold selectivity over hCCK1 receptor; has oral EC50 of 1.5 and 0.26 uM in conscious rat and dog chronic gastric fistula models of pentagastrin-stimulated acid secretion, respectively; inhibits gastric acid secretion and prevents omeprazole-induced acid rebound in the rats.
[References]
References 1. Morton MF, et al. J Pharmacol Exp Ther. 2011 Jul;338(1):328-36. 2. Barrett TD, et al. Br J Pharmacol. 2012 Jul;166(5):1684-93. View Related Products by Target Cholecystokinin Receptor
Chemical & Physical Properties
[ Molecular Formula ]:
C23H17BrF2N4O3S
[ Molecular Weight ]:
547.37