1-(5-ISOQUINOLINYLSULFONYL)-3-METHYL-PIPERAZINE

Names

[ Name ]:
1-(5-ISOQUINOLINYLSULFONYL)-3-METHYL-PIPERAZINE

[Synonym ]:
Piperazine,1-(5-isoquinolinylsulfonyl)-3-methyl
1-(5-Isoquinolinylsulfonyl)-3-methylpiperazine
5-[(3-methylpiperazin-1-yl)sulfonyl]isoquinoline
1-(5-isoquinolinesulfonyl)-3-methylpiperazine
Iso-H-7

Chemical & Physical Properties

[ Density]:
1.277 g/cm3

[ Boiling Point ]:
495.3ºC at 760 mmHg

[ Molecular Formula ]:
C₁₄H₁₇N₃O₂S

[ Molecular Weight ]:
291.36900

[ Flash Point ]:
253.3ºC

[ Exact Mass ]:
291.10400

[ PSA ]:
70.68000

[ LogP ]:
2.56470

[ Index of Refraction ]:
1.614

Safety Information

[ Personal Protective Equipment ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ Safety Phrases ]:
22-24/25

[ RIDADR ]:
NONH for all modes of transport

[ HS Code ]:
2935009090

Customs

[ HS Code ]: 2935009090

[ Summary ]:
2935009090 other sulphonamides VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:35.0%

Articles

Production of interleukin (IL)-6 and IL-8 by a choriocarcinoma cell line, BeWo.

Placenta 21(4) , 354-60, (2000)

To clarify the biological and pathological features of choriocarcinoma, we evaluated the in vitro production of cytokines by a choriocarcinoma cell line, BeWo. We measured the concentration of interle...

Epidermal growth factor-induced heterologous desensitization of the luteinizing hormone/choriogonadotropin receptor in a cell-free membrane preparation is associated with the tyrosine phosphorylation of the epidermal growth factor receptor.

Endocrinology 140(1) , 29-36, (1999)

Epidermal growth factor (EGF) attenuated hCG-stimulated adenylyl cyclase activity in rat luteal and follicular membranes. H7, an equipotent serine/threonine protein kinase inhibitor of cAMP-dependent ...

Alpha1-adrenergic regulation of peptidylglycine alpha-amidating monooxygenase gene expression in cultured rat cardiac myocytes: transcriptional studies and messenger ribonucleic acid stability.

Mol. Cell. Endocrinol. 154(1-2) , 89-100, (1999)

Peptidylglycine alpha-amidating monooxygenase (PAM; EC 1.14.17.3) is a bifunctional protein containing two enzymes that act sequentially to catalyse the alpha-amidation of neuroendocrine peptides. Pre...