2-Methyl-5-HT hydrochloride

Names

[ Name ]:
2-Methyl-5-HT hydrochloride

[Synonym ]:
2-Methylserotonin.HCl

Biological Activity

[Description]:

2-Methyl-5-HT hydrochloride (2-Methyl-5-hydroxytryptamine hydrochloride) is a potent and selective 5-HT3 receptor agonist. 2-Methyl-5-HT hydrochloride is shown to display anti-depressive-like effects[1].

[Target]

5-HT3 Receptor

[In Vivo]

2-Methyl-5-HT hydrochloride (2-Methyl-5-hydroxytryptamine hydrochloride) (i.p.; 3 mg/kg; 45 minutes) significantly decreases time of immobility as compared to controls thus showing anti-depressive-like effects[1]. Animal Model: Male Sprague-Dawley rats[1] Dosage: 3 mg/kg Administration: I.p.; 45 minutes Result: Significantly decreased time of immobility thus showing anti-depressive-like effects.

[References]

[1]. Sumaya IC, et al. Differential effects of a short-term high-fat diet in an animal model of depression in rats treated with the 5-HT3 receptor antagonist, ondansetron, the 5-HT3 receptor agonist, 2-methyl-5-HT, and the SSRI, fluoxetine. Pharmacol Biochem Behav. 2016 May;144:78-84.

Chemical & Physical Properties

[ Molecular Formula ]:
C₁₁H₁₅ClN₂O

[ Molecular Weight ]:
226.70300

[ Exact Mass ]:
226.08700

[ PSA ]:
62.04000

[ LogP ]:
3.18540

Safety Information

[ HS Code ]:
2933990090

Customs

[ HS Code ]: 2933990090

[ Summary ]:
2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%