NCH 51

Names

[ Name ]:
NCH 51

[Synonym ]:
Propanethioic acid, 2-methyl-, S-[7-oxo-7-[(4-phenyl-2-thiazolyl)amino]heptyl] ester
NCH 51
Cpd 51
PTACH
S-{7-Oxo-7-[(4-phenyl-1,3-thiazol-2-yl)amino]heptyl} 2-methylpropanethioate
thioisobutyric acid S-(6-(4-phenyl-2-thiazolylcarbamoyl)hexyl) ester

Biological Activity

[Description]:

PTACH (NCH-51) is a SAHA-based novel inhibitor of human HDAC. PTACH exerts potent growth inhibition against various human cancer cells, with EC50 values ranging from 1 to 10 μM.IC50 value: 1-10 μM (EC50)Target: HDACin vitro: In cancer cell growth inhibition assay, PTACH shows strong activity. PTACH inhibits various cancer cells with EC50 of 2.3, 9.1, 3.0, 2.6, 1.1, 4.5, 2.4, 5.0, and 4.5 μM for MDA-MB-231 breast cancer, SNB-78 central nervous system, HCT116 colon cancer, NCI-H226 lung cancer, LOX-IMVI melanoma, SK-OV-3 ovarian cancer, RXF-631L renal cancer, St-4 stomach cancer, and DU-145 prostate cancer.

[Related Catalog]:

Research Areas >> Cancer

[Target]

HDAC

[References]

[1]. Suzuki T, et al. Novel inhibitors of human histone deacetylases: design, synthesis, enzyme inhibition, and cancer cell growth inhibition of SAHA-based non-hydroxamates. J Med Chem. 2005 Feb 24;48(4):1019-1032.

[Related Small Molecules]

Chemical & Physical Properties

[ Density]:
1.2±0.1 g/cm3

[ Molecular Formula ]:
C₂₀H₂₆N₂O₂S₂

[ Molecular Weight ]:
390.563

[ Exact Mass ]:
390.143555

[ PSA ]:
112.60000

[ LogP ]:
5.49

[ Appearance of Characters ]:
white solid

[ Index of Refraction ]:
1.588

[ Storage condition ]:
-20℃

MSDS

Click to get detail MSDS

Safety Information

[ Symbol ]:

GHS05

[ Signal Word ]:
Danger

[ Hazard Statements ]:
H318-H413

[ Precautionary Statements ]:
P280-P305 + P351 + P338

[ Personal Protective Equipment ]:
dust mask type N95 (US);Eyeshields;Gloves

[ Hazard Codes ]:
Xi: Irritant;

[ Risk Phrases ]:
41

[ Safety Phrases ]:
26-39

[ RIDADR ]:
NONH for all modes of transport

[ HS Code ]:
2934100090

Customs

[ HS Code ]: 2934100090

[ Summary ]:
2934100090 other compounds containing an unfused thiazole ring (whether or not hydrogenated) in the structure VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:20.0%