6-Methoxy-8-nitroquinoline

Names

[ CAS No. ]:
85-81-4

[ Name ]:
6-Methoxy-8-nitroquinoline

[Synonym ]:
6-Methoxy-8-nitroquinoline
Quinoline, 6-methoxy-8-nitro-
MFCD00006802
EINECS 201-633-7

Chemical & Physical Properties

[ Density]:
1.3±0.1 g/cm3

[ Boiling Point ]:
373.1±27.0 °C at 760 mmHg

[ Melting Point ]:
158-160 °C(lit.)

[ Molecular Formula ]:
C₁₀H₈N₂O₃

[ Molecular Weight ]:
204.182

[ Flash Point ]:
179.4±23.7 °C

[ Exact Mass ]:
204.053497

[ PSA ]:
67.94000

[ LogP ]:
1.86

[ Vapour Pressure ]:
0.0±0.8 mmHg at 25°C

[ Index of Refraction ]:
1.646

MSDS

Click to get detail MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: VC0365000

CHEMICAL NAME :: Quinoline, 6-methoxy-8-nitro-

CAS REGISTRY NUMBER :: 85-81-4

BEILSTEIN REFERENCE NO. :: 0168992

LAST UPDATED :: 199612

DATA ITEMS CITED :: 2

MOLECULAR FORMULA :: C10-H8-N2-O3

MOLECULAR WEIGHT :: 204.20

WISWESSER LINE NOTATION :: T66 BNJ HO1 JNW

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

MUTATION DATA

TYPE OF TEST :: Mutation in microorganisms

TEST SYSTEM :: Bacteria - Salmonella typhimurium

DOSE/DURATION :: 100 nmol/plate

REFERENCE :: MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 58,11,1978

Safety Information

[ Symbol ]:

GHS07, GHS08

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H302 + H312 + H332-H315-H319-H335-H351

[ Precautionary Statements ]:
P261-P280-P305 + P351 + P338

[ Personal Protective Equipment ]:
Eyeshields;full-face particle respirator type N100 (US);Gloves;respirator cartridge type N100 (US);type P1 (EN143) respirator filter;type P3 (EN 143) respirator cartridges

[ Hazard Codes ]:
Xn: Harmful;

[ Risk Phrases ]:
R20/21/22;R36/37/38;R40

[ Safety Phrases ]:
S26-S27-S36/37/39

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
3

[ RTECS ]:
VC0365000

[ HS Code ]:
2933499090

Synthetic Route

Click to get detail synthetic route

Customs

[ HS Code ]: 2933499090

[ Summary ]:
2933499090. other compounds containing in the structure a quinoline or isoquinoline ring-system (whether or not hydrogenated), not further fused. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

Articles

Ring-substituted quinolines as potential anti-tuberculosis agents.

Bioorg. Med. Chem. 12(10) , 2501-8, (2004)

We report in vitro antimycobacterial properties of ring-substituted quinolines (series 1-4) constituting 56 analogues against drug-sensitive and drug-resistant M. tuberculosis H37Rv strains. The most ...

Primaquine-induced hemolytic anemia: formation and hemotoxicity of the arylhydroxylamine metabolite 6-methoxy-8-hydroxylaminoquinoline.

J. Pharmacol. Exp. Ther. 297(2) , 509-15, (2001)

Primaquine is an important antimalarial agent because of its activity against exoerythrocytic forms of Plasmodium spp. However, methemoglobinemia and hemolytic anemia are dose-limiting side effects of...