RY796 racemate

A novel potent, selective Kv2 channel inhibitor that potently inhibits Kv2.1 and Kv2.2 with IC50 of 0.14 and 0.09 uM, respectively; shows no significant activity against Kv1.2 and Kv7.1, and Cav channels; enhances GSIS in isolated wild-type (WT) mouse and human islets, but not in islets from Kv2.1(-/-) mice, enhances somatostatin release in isolated human and mouse islets.

References 1. Herrington J, et al. Mol Pharmacol. 2011 Dec;80(6):959-64. 2. Li XN, et al. J Pharmacol Exp Ther. 2013 Feb;344(2):407-16. View Related Products by Target Potassium Channel