DRV1 (GPR32) agonist C2A
Names
[ CAS No. ]:
862811-76-5
[ Name ]:
DRV1 (GPR32) agonist C2A
[Synonym ]:
Benzamide, 3,4-difluoro-N-[3-(3-methylimidazo[1,2-a]pyrimidin-2-yl)phenyl]-
3,4-Difluoro-N-[3-(3-methylimidazo[1,2-a]pyrimidin-2-yl)phenyl]benzamide
Biological Activity
[Description]:
DRV1 (GPR32) agonist C2A (NCGC00135472) is a synthetic molecule that activate human resolvin D1 receptor DRV1/GPR32 receptor with EC50 of 0.37 uM and 0.05 uM in β-arrestin and cAMP assays, respectively; elicits rapid impedance changes in cells overexpressing recombinant DRV1, stimulates phagocytosis of serum-treated zymosan at concentrations comparable with that of RvD1, the endogenous DRV1 ligand, in human macrophages; also significantly increases by these chemotypes in DRV1-transfected macrophages in live E. coli.
[References]
References 1. Chiang N, et al. Cell Chem Biol. 2018 Nov 19. pii: S2451-9456(18)30383-0. View Related Products by Target Other Targets
Chemical & Physical Properties
[ Density]:
1.4±0.1 g/cm3
[ Molecular Formula ]:
C20H14F2N4O
[ Molecular Weight ]:
364.348
[ Exact Mass ]:
364.113556
[ LogP ]:
3.72
[ Index of Refraction ]:
1.654