ALK5-IN-16i

A potent and selective ALK5 inhibitor with IC50 of 5.5 nM, displays 300-fold selecitvity over ALK3; inhibits Smad2/3 phosphorylation in A549 cells (IC50=79 nM); significantly decreases Smad2 phosphorylation in mouse skin after topical application; may serves as a potential new therapy for AGA.

References 1. Amada H, et al. Bioorg Med Chem. 2012 Dec 15;20(24):7128-38. View Related Products by Target TGF beta Receptor (TGFBR)