KKL-40
Names
[ CAS No. ]:
865285-47-8
[ Name ]:
KKL-40
[Synonym ]:
N-[5-(4-Fluorophenyl)-1,3,4-oxadiazol-2-yl]-3-(trifluoromethyl)benzamide
Benzamide, N-[5-(4-fluorophenyl)-1,3,4-oxadiazol-2-yl]-3-(trifluoromethyl)-
Biological Activity
[Description]:
A small-molecule inhibitor of bacterial ribosome rescue that exhibits broad-spectrum antimicrobial activity against bacteria grown in liquid culture; exhibited exceptional antimicrobial activity against both attenuated (LVS) and fully virulent strains of F. tularensis (Schu S4) in vitro with MIC of 0.12 and 0.44 ug/mL, respectively; arrests intracellular growth of F. tularensis during all stages of infection, does not affect macrophage viability or function.
[References]
References 1. Goralski TD, et al. Antimicrob Agents Chemother. 2016 May 23;60(6):3276-82. View Related Products by Target Bacterial
Chemical & Physical Properties
[ Density]:
1.5±0.1 g/cm3
[ Molecular Formula ]:
C16H9F4N3O2
[ Molecular Weight ]:
351.255
[ Exact Mass ]:
351.063080
[ LogP ]:
4.43
[ Index of Refraction ]:
1.570