CDK5 inhibitor 20-223
Names
[ CAS No. ]:
865317-30-2
[ Name ]:
CDK5 inhibitor 20-223
Biological Activity
[Description]:
CDK5 inhibitor 20-223 (CP 668863) potent, selective, ATP-competitive CDK2/5 inhibitor with IC50 of 6.0 and 8.8 nM for CDK2/CyclinE and CDK5/p35, with little to no activity against CDK1/4/6/7/9; decreases pRB (S807/811) and pFAK (S732) levels in CRC cell lines, effectively blocks the kinase activity of CDK2 and CDK5 in multiple CRC cell lines; reduces migration of CRC cells, reduces cell growth in a panel of human CRC cell lines with mean IC50 of 362 nM; effectively slows tumor progression in mice models.
[References]
References 1. Robb CM, et al. Oncotarget. 2017 Dec 28;9(4):5216-5232. View Related Products by Target Cyclin-dependent Kinase (CDK)
Chemical & Physical Properties
[ Molecular Formula ]:
C19H19N3O
[ Molecular Weight ]:
305.381