CMPF

Names

[ Name ]:
CMPF

[Synonym ]:
2-(2-carboxyethyl)-4-methyl-5-propylfuran-3-carboxylic acid
Cmpfpa
3-CARBOXY-4-METHYL-5-PROPYL-2-FURANPROPIONIC
C1F
3-carboxy-4-methyl-5-propyl-2-furanpropanoic acid
2-(2-Carboxyethyl)-4-methyl-5-propyl-3-furoic acid
2-Furanpropanoic acid, 3-carboxy-4-methyl-5-propyl-

Biological Activity

[Description]:

CMPF can be found in trace constituent of urine and blood. CMPF is a biomarker of type 2 diabetes. CMPF can act on the β cell and induces impaired mitochondrial function. CMPF decreases glucose-induced ATP accumulation, and induces oxidative stress. CMPF reverses hepatic lipid accumulation and improves insulin sensitivity in obese mice[1][2].

[Related Catalog]:

Research Areas >> Metabolic Disease

[References]

[1]. Prentice KJ, et al. The furan fatty acid metabolite CMPF is elevated in diabetes and induces β cell dysfunction. Cell Metab. 2014 Apr 1;19(4):653-66.

[2]. Prentice KJ, et al. CMPF, a Metabolite Formed Upon Prescription Omega-3-Acid Ethyl Ester Supplementation, Prevents and Reverses Steatosis. EBioMedicine. 2018 Jan;27:200-213.

Chemical & Physical Properties

[ Density]:
1.2±0.1 g/cm3

[ Boiling Point ]:
404.0±45.0 °C at 760 mmHg

[ Molecular Formula ]:
C₁₂H₁₆O₅

[ Molecular Weight ]:
240.252

[ Flash Point ]:
198.1±28.7 °C

[ Exact Mass ]:
240.099777

[ PSA ]:
87.74000

[ LogP ]:
2.63

[ Vapour Pressure ]:
0.0±1.0 mmHg at 25°C

[ Index of Refraction ]:
1.532