3,4-Dichloro-5-hydroxy-2(5H)-furanone
Names
[ CAS No. ]:
87-56-9
[ Name ]:
3,4-Dichloro-5-hydroxy-2(5H)-furanone
[Synonym ]:
3,4-dichloro-5-hydroxy-5H-furan-2-one
Dichloromalealdehydicaicd
EINECS 201-752-4
(2Z)-2,3-dichloro-4-oxobut-2-enoic acid
2-Butenoic acid, 2,3-dichloro-4-oxo-, (2Z)-
2,3-dichloro-4-oxo-cis-crotonic acid
2(5H)-Furanone, 3,4-dichloro-5-hydroxy-
(2Z)-2,3-Dichloro-4-oxo-2-butenoic acid
Mucochlorsure
MUCOCHLORICAICD
3,4-dichloro-5-hydroxyfuran-2(5H)-one
Mucochloric acid
Kyselina mukochlorova
MFCD00006966
2,3-Dichloro-4-oxobutenoic acid
Dichloromalealdehyde acid
aldehydodichloromaleicacid
Chemical & Physical Properties
[ Density]:
1.6±0.1 g/cm3
[ Boiling Point ]:
271.0±40.0 °C at 760 mmHg
[ Melting Point ]:
125-128 °C(lit.)
[ Molecular Formula ]:
C4H2Cl2O3
[ Molecular Weight ]:
168.963
[ Flash Point ]:
117.7±27.3 °C
[ Exact Mass ]:
167.938095
[ PSA ]:
54.37000
[ LogP ]:
0.19
[ Vapour Pressure ]:
0.0±1.2 mmHg at 25°C
[ Index of Refraction ]:
1.532
[ Water Solubility ]:
SOLUBLE IN HOT WATER
MSDS
Toxicological Information
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- AS7700000
- CHEMICAL NAME :
- Acrylic acid, 2,3-dichloro-3-formyl-
- CAS REGISTRY NUMBER :
- 87-56-9
- BEILSTEIN REFERENCE NO. :
- 1705641
- LAST UPDATED :
- 199710
- DATA ITEMS CITED :
- 16
- MOLECULAR FORMULA :
- C4-H2-Cl2-O3
- MOLECULAR WEIGHT :
- 168.96
- WISWESSER LINE NOTATION :
- VHYGUYGVQ
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- Standard Draize test
- ROUTE OF EXPOSURE :
- Administration onto the skin
- SPECIES OBSERVED :
- Rodent - rabbit
- TYPE OF TEST :
- Standard Draize test
- ROUTE OF EXPOSURE :
- Administration into the eye
- SPECIES OBSERVED :
- Rodent - rabbit
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 100 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 84 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rabbit
- DOSE/DURATION :
- 160 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - guinea pig
- DOSE/DURATION :
- 100 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 1218 mg/kg/9W-I
- TOXIC EFFECTS :
- Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - catalases Biochemical - Metabolism (Intermediary) - Plasma proteins not involving coagulation
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 6100 mg/kg/78W-I
- TOXIC EFFECTS :
- Tumorigenic - equivocal tumorigenic agent by RTECS criteria Lungs, Thorax, or Respiration - tumors Blood - tumors
MUTATION DATA
- TYPE OF TEST :
- Mutation in mammalian somatic cells
- TEST SYSTEM :
- Rodent - hamster Ovary
- DOSE/DURATION :
- 23700 nmol/L
- REFERENCE :
- EMMUEG Environmental and Molecular Mutagenesis. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.10- 1987- Volume(issue)/page/year: 25,284,1995 *** OCCUPATIONAL EXPOSURE LIMITS *** OEL-RUSSIA:STEL 0.1 mg/m3;Skin JAN 1993
Safety Information
[ Symbol ]:
GHS05, GHS06
[ Signal Word ]:
Danger
[ Hazard Statements ]:
H301-H314-H317
[ Precautionary Statements ]:
P280-P301 + P310-P305 + P351 + P338-P310
[ Personal Protective Equipment ]:
Eyeshields;Faceshields;full-face particle respirator type N100 (US);Gloves;respirator cartridge type N100 (US);type P1 (EN143) respirator filter;type P2 (EN 143) respirator cartridges;type P3 (EN 143) respirator cartridges
[ Hazard Codes ]:
T:Toxic;C:Corrosive;
[ Risk Phrases ]:
R25;R34;R37;R42/43
[ Safety Phrases ]:
S26-S36/37/39-S45-S22
[ RIDADR ]:
UN 2923 8/PG 3
[ WGK Germany ]:
2
[ RTECS ]:
AS7700000
[ Packaging Group ]:
III
[ Hazard Class ]:
8
[ HS Code ]:
29183000
Synthetic Route
Precursor & DownStream
Precursor
DownStream
Customs
[ HS Code ]: 29183000
Articles
Toxicology 100(1-3) , 69-77, (1995)
The cytotoxicity of the, in Salmonella, potent mutagenic compound, 3-chloro-4-(dichloromethyl)-5-hydroxy-2(5H)-furanone (MX) and its structural analogue 3,4-dichloro-5-hydroxy-2[5H]-furanone (mucochlo...
Test of chiral recognition in the Salmonella typhimurium (TA100) mutagenicity of mucochloric acid-cysteine adducts.Environ. Mol. Mutagen. 22(3) , 181-7, (1993)
A difference in biological response to enantiomers is not an uncommon observation and is, therefore, to be expected in various manifestations of genotoxicity. The bacterial mutagen mucochloric acid (2...
Effect of beta-cyclodextrin on mucochloric acid and 3-chloro-4-(dichloromethyl)-5-hydroxy-2(5H)-furanone.Arch. Environ. Contam. Toxicol. 20(3) , 371-4, (1991)
Cyclodextrins form inclusion complexes with a wide range of guest molecules which wholly, or in part, fit into their hydrophobic cavity. Since no covalent bonds are formed in this complexation, the gu...