Tetrachlorohydroquinone

Names

[ CAS No. ]:
87-87-6

[ Name ]:
Tetrachlorohydroquinone

[Synonym ]:
Tetrachlorohydroquinone
EINECS 201-779-1
MFCD00041748
2,3,5,6-tetrachlorobenzene-1,4-diol

Biological Activity

[Description]:

Tetrachlorohydroquinone (TCHQ) is a metabolite of pentachlorophenol. Tetrachlorohydroquinone increases DNA lesions and induce oxidative stress in rodents[1].

[Related Catalog]:

Research Areas >> Others

[References]

[1]. Pietsch C, et al. Cytotoxic effects of pentachlorophenol (PCP) and its metabolite tetrachlorohydroquinone (TCHQ) on liver cells are modulated by antioxidants. Cell Biol Toxicol. 2014 Aug;30(4):233-52.

Chemical & Physical Properties

[ Density]:
1.848 g/cm3

[ Boiling Point ]:
286.2ºC

[ Melting Point ]:
238-240 °C

[ Molecular Formula ]:
C₆H₂Cl₄O₂

[ Molecular Weight ]:
247.89

[ Flash Point ]:
126.9ºC

[ Exact Mass ]:
245.88100

[ PSA ]:
40.46000

[ LogP ]:
3.71140

[ Index of Refraction ]:
1.661

MSDS

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Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: MX7700000

CHEMICAL NAME :: Hydroquinone, tetrachloro-

CAS REGISTRY NUMBER :: 87-87-6

BEILSTEIN REFERENCE NO. :: 1876374

LAST UPDATED :: 199710

DATA ITEMS CITED :: 13

MOLECULAR FORMULA :: C6-H2-Cl4-O2

MOLECULAR WEIGHT :: 247.88

WISWESSER LINE NOTATION :: QR BG CG EG FG DQ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Unreported

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 3319 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 368 mg/kg

TOXIC EFFECTS :: Behavioral - somnolence (general depressed activity) Behavioral - tremor Behavioral - muscle weakness

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 25 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

MUTATION DATA

TYPE OF TEST :: DNA adduct

TEST SYSTEM :: Mammal - species unspecified Lymphocyte

DOSE/DURATION :: 50 mmol/L

REFERENCE :: MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 145,71,1985

Safety Information

[ Hazard Codes ]:
Xn: Harmful;

[ Risk Phrases ]:
22-41

[ Safety Phrases ]:
S26-S36/37/39-S39

[ RTECS ]:
MX7700000

[ HS Code ]:
2908199090

Synthetic Route

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Precursor & DownStream

Precursor

DownStream

Customs

[ HS Code ]: 2908199090

[ Summary ]:
HS: 2908199090. derivatives of polyphenols or phenol-alcohols containing only halogen substituents and their salts. VAT:17.0%. tax rebate rate:9.0%. supervision conditions:None. MFN tariff:5.5%. general tariff:30.0%