1,3-Dimethyluracil

Names

[ CAS No. ]:
874-14-6

[ Name ]:
1,3-Dimethyluracil

[Synonym ]:
N1,N3-Dimethyluracil
1,3-dimethylpyrimidine-2,4-dione
2,4(1H,3H)-Pyrimidinedione, 1,3-dimethyl-
1,3-Dimethyl-2,4(1H,3H)-pyrimidinedione
MFCD00038065
1,3-dimethyluracil
Uracil, 1,3-dimethyl-
1,3-dimethylpyrimidine-2,4(1H,3H)-dione
EINECS 212-856-4

Biological Activity

[Description]:

1,3-Dimethyluracil is a pyrimidone derives from a uracil. 1,3-Dimethyluracil found occasionally in human urine. 1,3-Dimethyluracil shows inhibition activity against hCA I and hCA II (human carbonic anhydrase) with Ki of 316.2 μM and 166.4 μM, respectively[1][2].

[Related Catalog]:

Research Areas >> Metabolic Disease

[References]

[1]. Stoessel D, et al. Promising Metabolite Profiles in the Plasma and CSF of Early Clinical Parkinson's Disease. Front Aging Neurosci. 2018 Mar 5;10:51.

[2]. Güney M, et al. Synthesis and carbonic anhydrase inhibitory properties of novel uracil derivatives. Bioorg Med Chem Lett. 2015 Aug 15;25(16):3261-3.

Chemical & Physical Properties

[ Density]:
1.2±0.1 g/cm3

[ Boiling Point ]:
208.4±23.0 °C at 760 mmHg

[ Melting Point ]:
119-122 °C(lit.)

[ Molecular Formula ]:
C₆H₈N₂O₂

[ Molecular Weight ]:
140.140

[ Flash Point ]:
84.3±15.0 °C

[ Exact Mass ]:
140.058578

[ PSA ]:
44.00000

[ LogP ]:
0.40

[ Vapour Pressure ]:
0.2±0.4 mmHg at 25°C

[ Index of Refraction ]:
1.519

MSDS

Click to get detail MSDS

Safety Information

[ Personal Protective Equipment ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ Hazard Codes ]:
Xi:Irritant;

[ Risk Phrases ]:
R36

[ Safety Phrases ]:
S22-S24/25-S39-S26

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
3

[ HS Code ]:
2933599090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Customs

[ HS Code ]: 2933599090

[ Summary ]:
2933599090. other compounds containing a pyrimidine ring (whether or not hydrogenated) or piperazine ring in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

Articles

Excited state structures and decay dynamics of 1,3-dimethyluracils in solutions: resonance Raman and quantum mechanical calculation study.

J. Phys. Chem. B 117(39) , 11660-9, (2013)

The resonance Raman spectroscopic study of the excited state structural dynamics of 1,3-dimethyluracil (DMU), 5-bromo-1,3-dimethyluracil (5BrDMU), uracil, and thymine in water and acetonitrile were re...

Ionization of dimethyluracil dimers leads to facile proton transfer in the absence of hydrogen bonds.

Nature Chemistry 4(4) , 323-9, (2012)

Proton transfer is ubiquitous in chemistry and biology, occurring, for example, in proteins, enzyme reactions and across proton channels and pumps. However, it has always been described in the context...

The SO4(.-)-induced chain reaction of 1,3-dimethyluracil with peroxodisulphate.

Int. J. Radiat. Biol. Relat. Stud. Phys. Chem. Med. 51(3) , 441-53, (1987)

The sulphate radical SO4(.-) reacts with 1,3-dimethyluracil (1,3-DMU) (k = 5 X 10(9) dm3 mol-1 s-1) thereby forming with greater than or equal to 90 per cent yield the 1,3-DMU C(5)-OH adduct radical 4...