UoS 12258

Names

[ Name ]:
UoS 12258

[Synonym ]:
2-Propanesulfonamide, N-[(2S)-5-(6-fluoro-3-pyridinyl)-2,3-dihydro-1H-inden-2-yl]-
N-[(2S)-5-(6-Fluoro-3-pyridinyl)-2,3-dihydro-1H-inden-2-yl]-2-propanesulfonamide

Biological Activity

[Description]:

UoS12258 (UoS-12258) is a selective, positive allosteric modulator of the AMPA receptor with pEC50 of 5.6; displays excellent wide selectivity against a wide range of other ion channels (including hERG, NMDA, and kainate channels), enzymes, and GPCRs; displays a minimum effective concentration of approximately 10 nM in vitro and enhances AMPA receptor-mediated synaptic transmission at an estimated free brain concentration of approximately 15 nM in vivo; exhibits cognition enhancing properties in several rat behavioural models.

[References]

References 1. Ward SE, et al. J Med Chem. 2010 Aug 12;53(15):5801-12. 2. Ward SE, et al. Br J Pharmacol. 2017 Mar;174(5):370-385. View Related Products by Target iGluR

Chemical & Physical Properties

[ Density]:
1.3±0.1 g/cm3

[ Boiling Point ]:
502.5±60.0 °C at 760 mmHg

[ Molecular Formula ]:
C₁₇H₁₉FN₂O₂S

[ Molecular Weight ]:
334.408

[ Flash Point ]:
257.7±32.9 °C

[ Exact Mass ]:
334.115112

[ LogP ]:
2.68

[ Vapour Pressure ]:
0.0±1.3 mmHg at 25°C

[ Index of Refraction ]:
1.604

UoS 12258

Names

Biological Activity

Chemical & Physical Properties

Related Compounds